ArticleRheumatology international2016
The associations of serum uric acid level and hyperuricemia with knee osteoarthritis.
Article in Rheumatology international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- Prevalence and Severity of Spinal Osteoarthritis in Gout Patients Versus Non-Gout Controls.Gout, urate, and crystal deposition disease · 2026Article
- The association between the uric acid-to-high-density lipoprotein cholesterol ratio and osteoarthritis risk in U.S. adults: a cross-sectional study based on NHANES 1999-2016.Lipids in health and disease · 2025Article
- The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.Frontiers in endocrinology · 2025Review
- Gout and Hyperuricemia: A Narrative Review of Their Comorbidities and Clinical Implications.Journal of clinical medicine · 2024Review
- Anti-gouty arthritis and anti-inflammatory effects of curcumin nanoparticles in monosodium urate crystals induced Balb/C mice.Inflammopharmacology · 2024Article
- Association between asymptomatic hyperuricemia and risk of arthritis, findings from a US National Survey 2007-2018.BMJ open · 2024Article
- Association between hyperuricaemia and hand osteoarthritis: data from the Xiangya Osteoarthritis Study.RMD open · 2023Observational
- ULTRASONOGRAPHIC EVALUATION OF FEMORAL CARTILAGE THICKNESS IN PARTICIPANTS WITH ASYMPTOMATIC HYPERURICEMIA: A CASE-CONTROL STUDY.Acta clinica Croatica · 2023Article
- TSkeletal radiology · 2022Article
- Effect of resveratrol on abnormal bone remodeling and angiogenesis of subchondral bone in osteoarthritis.International journal of clinical and experimental pathology · 2021Article
- CD44 Receptor Mediates Urate Crystal Phagocytosis by Macrophages and Regulates Inflammation in A Murine Peritoneal Model of Acute Gout.Scientific reports · 2020Article
- Urate and osteoarthritis: Evidence for a reciprocal relationship.Joint bone spine · 2019Review
- The association between asymptomatic hyperuricemia and knee osteoarthritis: data from the third National Health and Nutrition Examination Survey.Osteoarthritis and cartilage · 2019Article
- Serum uric acid level is not associated with osteoarthritis in Korean population: data from the Seventh Korea National Health and Nutrition Examination Survey 2016.Rheumatology international · 2018Article
- Osteoarthritis year in review 2017: clinical.Osteoarthritis and cartilage · 2018Review
- Association between metabolic syndrome and knee osteoarthritis: a cross-sectional study.BMC musculoskeletal disorders · 2017Observational
- Gout and risk of knee replacement for severe knee osteoarthritis in the Singapore Chinese Health Study.Osteoarthritis and cartilage · 2017Article
- Relationship between cigarette smoking and hyperuricemia in middle-aged and elderly population: a cross-sectional study.Rheumatology international · 2017Article
- Exploring the Link between Uric Acid and Osteoarthritis.Frontiers in medicine · 2017Review
- Gout and Osteoarthritis: Associations, Pathophysiology, and Therapeutic Implications.Current rheumatology reports · 2016Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the cross-sectional associations of the serum uric acid level and hyperuricemia (HU) with the radiographic features of osteoarthritis (OA), including osteophytes (OST) and joint space narrowing (JSN), a total of 4685 subjects were included in this study. Blood samples were drawn from all subjects. Serum uric acid and some other indexes were detected. OST and JSN were assessed for each subject according to the Osteoarthritis Research Society International (OARSI) atlas. A multivariable logistic analysis model was applied to test the target associations after adjusting a number of potential confounding factors. The prevalence of OST was increased in the highest tertile of uric acid compared to the lowest in female subjects (OR 1.46, 95 % CI 1.07-1.99, P for trend = 0.02). Meanwhile, a positive association between OST and HU was observed in female subjects (OR 1.43, 95 % CI 1.01-2.03, P = 0.05). However, serum uric acid and HU were not significantly associated with JSN in male subjects. The findings of this study indicated that the serum uric acid concentration and prevalence of HU are positively associated with OST of the knee in the female population. Level of evidence Cross-sectional study, Level III.
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