ArticleLung2016
Muscular Dysfunction in COPD: Systemic Effect or Deconditioning?
Article in Lung, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise capacity and physical activity in COPD patients treated with a LAMA/LABA combination: a systematic review and meta-analysis.Respiratory research · 2022Pooled it
- Effect of Eccentric Cycling on Oxygen Uptake and Hemodynamics in Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Crossover Trial.Respiration; international review of thoracic diseases · 2025Trial
- Effects of eccentric vs concentric cycling training on patients with moderate COPD.European journal of applied physiology · 2022Trial
- Effects of Pulmonary Rehabilitation on Dyspnea, Quality of Life and Cognitive Function in COPD: A Systematic Review.Journal of clinical medicine · 2026Review
- Role of ultrasonography in assessing respiratory muscle loss: insights from a cross-sectional study on neurological patients with long-term bed rest with and without tracheostomy.BMC pulmonary medicine · 2025Article
- Article
- The Role of the Cumulative Illness Rating Scale (CIRS) in Estimating the Impact of Comorbidities on Chronic Obstructive Pulmonary Disease (COPD) Outcomes: A Pilot Study of the MACH (Multidimensional Approach for COPD and High Complexity) Study.Journal of personalized medicine · 2023Article
- Roles of sirtuin family members in chronic obstructive pulmonary disease.Respiratory research · 2022Review
- Mapping the global research landscape and hotspot of exercise therapy and chronic obstructive pulmonary disease: A bibliometric study based on the web of science database from 2011 to 2020.Frontiers in physiology · 2022Article
- Is the Power Spectrum of Electromyography Signal a Feasible Tool to Estimate Muscle Fiber Composition in Patients with COPD?Journal of clinical medicine · 2021Article
- Correlation between disease severity factors and EQ-5D utilities in chronic obstructive pulmonary disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Exercise and Chronic Obstructive Pulmonary Disease (COPD).Advances in experimental medicine and biology · 2020Review
- Handgrip Strength and Pulmonary Disease in the Elderly: What is the Link?Aging and disease · 2019Review
- Ischiocrural Strength May Be a Better Prognostic Marker Than Quadriceps Strength in COPD.Lung · 2018Article
- Impact of Previous Physical Activity Levels on Symptomatology, Functionality, and Strength during an Acute Exacerbation in COPD Patients.Healthcare (Basel, Switzerland) · 2018Article
- Raw BIA variables are predictors of muscle strength in patients with chronic obstructive pulmonary disease.European journal of clinical nutrition · 2017Article
- Understanding the impact of symptoms on the burden of COPD.Respiratory research · 2017Review
- Article
- Advances in the Evaluation of Respiratory Pathophysiology during Exercise in Chronic Lung Diseases.Frontiers in physiology · 2017Review
- Exertional dyspnoea in COPD: the clinical utility of cardiopulmonary exercise testing.European respiratory review : an official journal of the European Respiratory Society · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMuscular dysfunction has been described as one of the systemic manifestations of chronic obstructive pulmonary disease (COPD).
objectiveThe aim of this study was to evaluate muscular strength of the different anatomical compartments in patients with severe COPD compared with healthy controls.
methodWe performed a cross-sectional study in patients with severe COPD. We evaluated the muscular strength of the respiratory muscles, flexors and extensors of the cervical spine and knee, as well as handgrip force. The 6-min walking test (6MWT) and serum inflammatory markers were also analysed.
resultsTwenty-eight male patients with COPD (mean age 67.8 years, mean FEV1 (%) 39 %) and 24 male healthy controls (mean age 70.2 years) were studied. The strength of the flexors and extensors of the knee was significantly reduced in patients with COPD (p < 0.001 and p = 0.003). No differences were observed in the flexors and extensors of the cervical spine and handgrip force between groups. No correlation was observed between the muscular strength in the different anatomic compartments and the concentrations of blood inflammatory biomarkers or the metres walked in the 6MWT in COPD patients. However, a significant negative linear correlation was observed between the 6MWT and IL-6 and IL-8 levels (rho = -0.67, p = 0.001; rho = -0.57, p = 0.008). In addition, we found a negative correlation between the 6MWT and inspiratory capacity (rho = -0.755, p = 0.031).
conclusionsOur results suggest that muscular dysfunction in patients with COPD differs in different muscular compartments. The main factor for a reduced exercise capacity was a reduction in inspiratory capacity.
Indexed as
Identifiers
26743191What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.