The SPRINT study: Outcome may be driven by difference in diuretic treatment demasking heart failure and study design may support systolic blood pressure target below 140 mmHg rather than below 120 mmHg.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

14 citing papers in PubMed.

1. Impact of Antihypertensive Drug Class on Outcomes in SPRINT.Hypertension (Dallas, Tex. : 1979) · 2022
   Trial
2. Final Report of a Trial of Intensive versus Standard Blood-Pressure Control.The New England journal of medicine · 2021
   Trial
3. Heart Failure Prevention in Older Patients Using Intensive Blood Pressure Reduction: Potential Role of Diuretics.JACC. Heart failure · 2019
   Trial
4. A meta-analysis of the long-term effects of antihypertensive therapy on the risk of major cardiovascular disease across 51 randomized trials.Nature medicine · 2026
   Article
5. SPRINT Revisited: Updated Results and Implications.Hypertension (Dallas, Tex. : 1979) · 2021
   Review
6. Therapeutic Stalemate in Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2021
   Review
7. Impact of SPRINT results on hypertension guidelines: implications for "frail" elderly patients.Journal of human hypertension · 2018
   Review
8. New guidelines with few takers: will the new American guidelines ever be accepted?Journal of human hypertension · 2018
   Article
9. Which Target Blood Pressure in Year 2018? Evidence from Recent Clinical Trials.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2018
   Review
10. Blood pressure targets in the elderly.Journal of hypertension · 2018
    Article
11. Hypertension Across the Atlantic: A Sprint or a Marathon?High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2017
    Article
12. Blood pressure treatment goals in hypertension.Therapeutic advances in cardiovascular disease · 2016
    Article
13. Hypertension and coronary artery disease: epidemiology, physiology, effects of treatment, and recommendations : A joint scientific statement from the Austrian Society of Cardiology and the Austrian Society of Hypertension.Wiener klinische Wochenschrift · 2016
    Article
14. Hypertension: When should we treat hypertension in patients with diabetes?Nature reviews. Cardiology · 2016
    Article

Corrections and comments

• Comment on
  The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT).2014

Authors and funding

4 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as