Evidence map›Paper›PMID 26743100›Full record

Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2016

Problem-Solving Therapy Reduces Suicidal Ideation In Depressed Older Adults with Executive Dysfunction.

Kristen A Gustavson, George S Alexopoulos, Grace C Niu, Charles McCulloch, Tanya Meade, Patricia A Areán

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00052091 (PST in Geriatric Depression With Executive Dysfunction), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00052091 phase3completednot on this map

PST in Geriatric Depression With Executive Dysfunction

TypeinterventionalSponsorUniversity of WashingtonRan2002 to 2008Enrolled221ConditionsDepression, Cognition DisordersArmsProblem Solving Therapy, Brief Supportive Therapy
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 101 citations in OpenAlex.

  1. Trial
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  6. Predicting Next-Day Passive Suicidal Ideation in At-Risk Youth.Suicide & life-threatening behavior · 2026
    Article
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  8. Review
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  12. Review
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  15. Article
  16. Suicide in late life: A viewpoint.Preventive medicine · 2021
    Article
  17. Late Life Depression: The Essentials and the Essential Distinctions.Focus (American Psychiatric Publishing) · 2021
    Article
  18. Problem-Solving Therapy Effects on Suicidal Ideation: The Role of Reduction in Functional Disability.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021
    Article
  19. Article
  20. Predictors of serious suicidal behavior in late-life depression.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Kristen A GustavsonDepartment of Psychiatry, University of California, San Francisco, CA, USA.
George S AlexopoulosDepartment of Psychiatry, Weill-Cornell Medical College, New York, NY, USA.
Grace C NiuDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Charles McCullochDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Tanya MeadeSchool of Social Sciences and Psychology, University of Western Sydney, Australia.
Patricia A AreánDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Electronic address: parean@uw.edu.
University of California, San Francisco · USCornell University · USUniversity of Washington · USWestern Sydney University · AU

Funding

Research Methods CoreP30MH085943 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI ALEXOPOULOS, GEORGE S · 2009 to 2013
$9.2M
CLINICAL SERVICES RESEARCH TRAINING PROGRAMT32MH018261 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaja Zabrina LeWinn, Rachel L. Loewy · 1985 to 2026
$7.0M
RESEARCH TRAINING IN GERIATRIC MOOD DISORDERST32MH019132 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUNNING, FAITH M · 1990 to 2025
$3.4M
PST in Geriatric Depression with Executive DysfunctionR01MH063982 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AREAN, PATRICIA A. · 2002 to 2006
$1.9M
Treating Depression in Low-Income Elderly with CIND/AMCIK24MH074717 · NIMH · UNIVERSITY OF WASHINGTON · PI AREAN, PATRICIA A. · 2005 to 2016
$1.7M
NIMHD NIH HHS L60 MD006267NIMH NIH HHS K24 MH074717NIMH NIH HHS P30 MH085943NIMH NIH HHS R01 MH063982NIMH NIH HHS T32 MH018261NIMH NIH HHS T32 MH019132NIMH NIH HHS T32MH019132
6 · The paper itself

Abstract

objectiveTo test the hypothesis that Problem Solving Therapy (PST) is more effective than Supportive Therapy (ST) in reducing suicidal ideation in older adults with major depression and executive dysfunction. We further explored whether patient characteristics, such as age, sex, and additional cognitive impairment load (e.g., memory impairments) were related to changes in suicidal ideation over time.

designSecondary data analysis using data from a randomized clinical trial allocating participants to PST or ST at 1:1 ratio. Raters were blind to patients' assignments.

settingUniversity medical centers.

participants221 people aged 65 years old and older with major depression determined by Structured Clinical Interview for DSM-III-R diagnosis and executive dysfunction as defined by a score of 33 or less on the Initiation-Perseveration Score of the Mattis Dementia Rating Scale or a Stroop Interference Task score of 25 or less.

interventions12 weekly sessions of PST or ST.

main outcome measuresThe suicide item of the Hamilton Depression Rating Scale.

resultsOf the 221 participants, 61% reported suicidal ideation (SI). The ST group had a lower rate of improvement in SI after 12 weeks (44.6%) than did the PST group (60.4%, Fisher's exact test p = 0.031). Logistic regression showed significantly greater reductions in SI in elders who received PST at both 12 weeks (OR: .50, Z = -2.16, p = 0.031) and 36 weeks (OR: 0.5, Z = -1.96, p = 0.05) after treatment.

conclusionsPST is a promising intervention for older adults who are at risk for suicide. ClinicalTrials.gov Identifier: NCT00052091.

Indexed as

Problem SolvingSuicidal IdeationAgedAged, 80 and overCognition DisordersDiagnostic and Statistical Manual of Mental DisordersExecutive FunctionFemaleHumansMajor Depressive DisorderMaleMiddle AgedPsychiatric Status Rating ScalesPsychotherapyTreatment OutcomeDepressionexecutive dysfunctionolder adultsproblem-solving therapysuicide ideation

Identifiers

PMID26743100
PMCPMC5730069
OpenAlexW1182846970

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.