ArticleScientific reports2016
Unearthing the Antibacterial Mechanism of Medicinal Clay: A Geochemical Approach to Combating Antibiotic Resistance.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 145 citations in OpenAlex.
- DermominaFrontiers in endocrinology · 2026Observational
- Immobilization of Trypsin and Lysozyme in Halloysite Nanotubes for Producing Chitosan Coatings with Antibacterial Properties.Polymers · 2025Article
- Photocurable hydrogel containing MOF nanoenzymes for comprehensive pulpitis treatment: antibacterial, anti-inflammatory, and osteogenic actions.Journal of nanobiotechnology · 2025Article
- Modification of Natural Clays with Magnetite to Provide Boosted Antimicrobial Properties and Chemopreventive Activity Against Melanoma.Materials (Basel, Switzerland) · 2025Article
- Optimization of degradation conditions and elucidation of novel biodegradation pathways for sulfamonomethoxine by a novelApplied and environmental microbiology · 2025Article
- Mineral-Based Advanced Oxidation Processes for Enhancing the Removal of Antibiotic Resistance Genes from Domestic Wastewater.ACS ES&T water · 2025Article
- Alternatives to antibiotics for sustainable livestock production in the context of the One Health approach: tackling a common foe.Frontiers in veterinary science · 2025Review
- Exploring antimicrobial interactions between metal ions and quaternary ammonium compounds toward synergistic metallo-antimicrobial formulations.Microbiology spectrum · 2024Article
- The application of synthetic antibacterial minerals to combat topical infections: exploring a mouse model of MRSA infection.Scientific reports · 2024Article
- Effect of Padzahr Tablet on Biochemical Indices of Bone Remodeling in Postmenopausal Females with Osteopenia: A Randomized Double-Blind Placebo-Controlled Trial.Galen medical journal · 2024Article
- Optimization of process parameters for trimethoprim and sulfamethoxazole removal by magnetite-chitosan nanoparticles using Box-Behnken design.Scientific reports · 2023Article
- Antibacterial Activity of a Natural Clay Mineral againstMicroorganisms · 2023Article
- A Review of Pickering Emulsions: Perspectives and Applications.Pharmaceuticals (Basel, Switzerland) · 2022Review
- The Effects of Blue Light on Human Fibroblasts and Diabetic Wound Healing.Life (Basel, Switzerland) · 2022Review
- A Mini Review of Antibacterial Properties of AlNanomaterials (Basel, Switzerland) · 2022Review
- Synthetic antibacterial minerals: harnessing a natural geochemical reaction to combat antibiotic resistance.Scientific reports · 2022Article
- Article
- NanoSIP: NanoSIMS Applications for Microbial Biology.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Article
- Buruli Ulcer and Medical Geo-Microbiology.Infection and drug resistance · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Natural antibacterial clays, when hydrated and applied topically, kill human pathogens including antibiotic resistant strains proliferating worldwide. Only certain clays are bactericidal; those containing soluble reduced metals and expandable clay minerals that absorb cations, providing a capacity for extended metal release and production of toxic hydroxyl radicals. Here we show the critical antibacterial components are soluble Fe(2+) and Al(3+) that synergistically attack multiple cellular systems in pathogens normally growth-limited by Fe supply. This geochemical process is more effective than metal solutions alone and provides an alternative antibacterial strategy to traditional antibiotics. Advanced bioimaging methods and genetic show that Al(3+) misfolds cell membrane proteins, while Fe(2+) evokes membrane oxidation and enters the cytoplasm inflicting hydroxyl radical attack on intracellular proteins and DNA. The lethal reaction precipitates Fe(3+)-oxides as biomolecular damage proceeds. Discovery of this bactericidal mechanism demonstrated by natural clays should guide designs of new mineral-based antibacterial agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.