Evidence map›Paper›PMID 26742935›Full record

ArticleJournal of endocrinological investigation2016

Clinical presentation and management of patients with primary hyperparathyroidism of the Swiss Primary Hyperparathyroidism Cohort: a focus on neuro-behavioral and cognitive symptoms.

A Trombetti, E R Christ, C Henzen, G Gold, M Brändle, F R Herrmann, C Torriani, F Triponez, M Kraenzlin, R Rizzoli and 1 more

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Article in Journal of endocrinological investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Parathyroidectomy for adults with primary hyperparathyroidism.The Cochrane database of systematic reviews · 2023
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

A TrombettiBone Diseases Service, Department of Internal Medicine Specialties, Geneva University Hospitals and Faculty of Medicine, Rue Gabrielle Perret-Gentil 4, 1211, Geneva 14, Switzerland. Andrea.Trombetti@hcuge.ch.
E R ChristDivision of Endocrinology, Diabetes, and Clinical Nutrition, Bern University Hospital, Freiburgstrasse 4, 3010, Bern, Switzerland.
C HenzenDepartment of Medicine, Kantonsspital, Spitalstrasse, Lucerne, Switzerland.
G GoldDivision of Geriatrics, Geneva University Hospitals and Faculty of Medicine, Rue Gabrielle Perret-Gentil 4, 1211, Geneva 14, Switzerland.
M BrändleDivision of Endocrinology and Diabetes, Department of Internal Medicine, Kantonsspital St. Gallen, Rorschacher Strasse 95, 9007, St. Gallen, Switzerland.
F R HerrmannBone Diseases Service, Department of Internal Medicine Specialties, Geneva University Hospitals and Faculty of Medicine, Rue Gabrielle Perret-Gentil 4, 1211, Geneva 14, Switzerland.
C TorrianiBone Diseases Service, Department of Internal Medicine Specialties, Geneva University Hospitals and Faculty of Medicine, Rue Gabrielle Perret-Gentil 4, 1211, Geneva 14, Switzerland.
F TriponezThoracic and Endocrine Surgery, Geneva University Hospitals, Rue Gabrielle Perret-Gentil 4, 1211, Geneva 14, Switzerland.
M KraenzlinDivision of Endocrinology, Diabetes and Metabolism, Universitätsspital Basel, Spitalstrasse 21/Petersgraben, 4031, Basel, Switzerland.
R RizzoliBone Diseases Service, Department of Internal Medicine Specialties, Geneva University Hospitals and Faculty of Medicine, Rue Gabrielle Perret-Gentil 4, 1211, Geneva 14, Switzerland.
C MeierDivision of Endocrinology, Diabetes and Metabolism, Universitätsspital Basel, Spitalstrasse 21/Petersgraben, 4031, Basel, Switzerland.
University Hospital of Geneva · CHUniversity Hospital of Basel · CHKantonsspital St. Gallen · CHLuzerner Kantonsspital · CHUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe the clinical and biochemical profile of patients with primary hyperparathyroidism (PHPT) of the Swiss Hyperparathyroidism Cohort, with a focus on neurobehavioral and cognitive symptoms and on their changes in response to parathyroidectomy.

methodsFrom June 2007 to September 2012, 332 patients were enrolled in the Swiss PHPT Cohort Study, a nationwide prospective and non-interventional project collecting clinical, biochemical, and outcome data in newly diagnosed patients. Neuro-behavioral and cognitive status were evaluated annually using the Mini-Mental State Examination, the Hospital Anxiety and Depression Scale, and the Clock Drawing tests. Follow-up data were recorded every 6 months. Patients with parathyroidectomy had one follow-up visit 3-6 months' postoperatively.

resultsSymptomatic PHPT was present in 43 % of patients. Among asymptomatic patients, 69 % (131/189) had at least one of the US National Institutes for Health criteria for surgery, leaving thus a small number of patients with cognitive dysfunction or neuropsychological symptoms, but without any other indication for surgery. At baseline, a large proportion showed elevated depression and anxiety scores and cognitive dysfunction, but with no association between biochemical manifestations of the disease and test scores. In the 153 (46 %) patients who underwent parathyroidectomy, we observed an improvement in the Mini-Mental State Examination (P = 0.01), anxiety (P = 0.05) and depression (P = 0.05) scores.

conclusionPHPT patients often present elevated depression and anxiety scores and cognitive dysfunction, but rarely as isolated manifestations. These alterations may be relieved upon treatment by parathyroidectomy.

Indexed as

ParathyroidectomyAgedAged, 80 and overAnxietyCognition DisordersDepressionDisease ManagementFemaleFollow-Up StudiesHumansHyperparathyroidism, PrimaryLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsPrognosisAnxietyClinical profileDepressionParathyroidectomy

Identifiers

PMID26742935
OpenAlexW2228346039

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.