ArticleThe Journal of biological chemistry2016
Cell Adhesion on Amyloid Fibrils Lacking Integrin Recognition Motif.
Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Amyloid-β 1-42 fibrils regulate SH-SY5Y cell adhesion in a delayed manner.Journal of Alzheimer's disease : JAD · 2026Article
- Aromatic residue-rich amino-terminal segments of temporin L self-assemble into collagen-mimetic peptides with cell-adhesion properties.The Journal of biological chemistry · 2026Article
- Engineering macromolecular crowding-driven amyloid-mineral hybrid scaffolds for enhanced bone regeneration.Bioactive materials · 2026Article
- From Pathology to Materials Science and Engineering: Harnessing the Amyloid State for Biotechnological Applications.ACS applied materials & interfaces · 2025Review
- Untargeted Discovery and Localization of Isomerized Residues in Neuropeptides.Analytical chemistry · 2025Article
- Amyloid-Templated Ceria Nanozyme Reinforced Microneedle for Diabetic Wound Treatments.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Isoaspartate-containing galanin in rat hypothalamus.Communications chemistry · 2025Article
- Fava Bean Protein Nanofibrils Modulate Cell Membrane Interfaces for Biomolecular Interactions as Unveiled by Atomic Force Microscopy.Foods (Basel, Switzerland) · 2024Article
- Amyloid Fibrils Enhance the Topical Bio-Adhesivity of Liquid Crystalline Mesophase-Based Drug Formulations.Advanced healthcare materials · 2023Article
- Amyloid-Based Albumin Hydrogels.Advanced healthcare materials · 2023Article
- Adaptive liquid interfaces induce neuronal differentiation of mesenchymal stem cells through lipid raft assembly.Nature communications · 2022Article
- Amphiphilic Histidine-Based Oligopeptides Exhibit pH-Reversible Fibril Formation.ACS macro letters · 2021Article
- Collective Cell Migration in a Fibrous Environment: A Hybrid Multiscale Modelling Approach.Frontiers in applied mathematics and statistics · 2021Article
- Apoferritin Amyloid-Fibril Directed the In Situ Assembly and/or Synthesis of Optical and Magnetic Nanoparticles.Nanomaterials (Basel, Switzerland) · 2021Article
- Rational Biological Interface Engineering: Amyloidal Supramolecular Microstructure-Inspired Hydrogel.Frontiers in bioengineering and biotechnology · 2021Review
- Directionality of Macrophages Movement in Tumour Invasion: A Multiscale Moving-Boundary Approach.Bulletin of mathematical biology · 2020Article
- Curcumin Inhibits the Primary Nucleation of Amyloid-Beta Peptide: A Molecular Dynamics Study.Biomolecules · 2020Article
- Biomimetic peptide self-assembly for functional materials.Nature reviews. Chemistry · 2020Article
- Polypeptides derived from α-Synuclein binding partners to prevent α-Synuclein fibrils interaction with and take-up by cells.PloS one · 2020Article
- Morphological Determinants of Carbon Nanomaterial-Induced Amyloid Peptide Self-Assembly.Frontiers in chemistry · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyloids are highly ordered, cross-β-sheet-rich protein/peptide aggregates associated with both human diseases and native functions. Given the well established ability of amyloids in interacting with cell membranes, we hypothesize that amyloids can serve as universal cell-adhesive substrates. Here, we show that, similar to the extracellular matrix protein collagen, amyloids of various proteins/peptides support attachment and spreading of cells via robust stimulation of integrin expression and formation of integrin-based focal adhesions. Additionally, amyloid fibrils are also capable of immobilizing non-adherent red blood cells through charge-based interactions. Together, our results indicate that both active and passive mechanisms contribute to adhesion on amyloid fibrils. The present data may delineate the functional aspect of cell adhesion on amyloids by various organisms and its involvement in human diseases. Our results also raise the exciting possibility that cell adhesivity might be a generic property of amyloids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.