Evidence map›Paper›PMID 26742795›Full record

ArticleStroke2016

Patterns and Implications of Intracranial Arterial Remodeling in Stroke Patients.

Ye Qiao, Zeeshan Anwar, Jarunee Intrapiromkul, Li Liu, Steven R Zeiler, Richard Leigh, Yiyi Zhang, Eliseo Guallar, Bruce A Wasserman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. MR Intracranial Vessel Wall Imaging: A Systematic Review.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020
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63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ye QiaoFrom The Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD (Y.Q., Z.A., J.I., L.L., B.A.W.); Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD (S.R.Z., R.L.); and Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (Y.Z., E.G.).
Zeeshan AnwarFrom The Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD (Y.Q., Z.A., J.I., L.L., B.A.W.); Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD (S.R.Z., R.L.); and Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (Y.Z., E.G.).
Jarunee IntrapiromkulFrom The Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD (Y.Q., Z.A., J.I., L.L., B.A.W.); Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD (S.R.Z., R.L.); and Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (Y.Z., E.G.).
Li LiuFrom The Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD (Y.Q., Z.A., J.I., L.L., B.A.W.); Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD (S.R.Z., R.L.); and Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (Y.Z., E.G.).
Steven R ZeilerFrom The Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD (Y.Q., Z.A., J.I., L.L., B.A.W.); Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD (S.R.Z., R.L.); and Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (Y.Z., E.G.).
Richard LeighFrom The Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD (Y.Q., Z.A., J.I., L.L., B.A.W.); Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD (S.R.Z., R.L.); and Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (Y.Z., E.G.).
Yiyi ZhangFrom The Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD (Y.Q., Z.A., J.I., L.L., B.A.W.); Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD (S.R.Z., R.L.); and Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (Y.Z., E.G.).
Eliseo GuallarFrom The Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD (Y.Q., Z.A., J.I., L.L., B.A.W.); Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD (S.R.Z., R.L.); and Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (Y.Z., E.G.).
Bruce A WassermanFrom The Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD (Y.Q., Z.A., J.I., L.L., B.A.W.); Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD (S.R.Z., R.L.); and Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (Y.Z., E.G.). bwasser@jhmi.edu.

Funding

The Intracranial Atherosclerotic Disease and Cognitive Impairment StudyR01HL105930 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SURI, MUHAMMAD FAREED, WASSERMAN, BRUCE A · 2011 to 2014
$2.7M
The Intracranial Atherosclerotic Disease and Cognitive Impairment StudyR01HL105626 · NHLBI · UNIVERSITY OF MINNESOTA · PI SURI, MUHAMMAD FAREED, WASSERMAN, BRUCE A · 2011 to 2014
$1.3M
MRI of Intracranial AtherosclerosisR00HL106232 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI QIAO, YE · 2014 to 2016
$739k
MRI of Intracranial AtherosclerosisK99HL106232 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI QIAO, YE · 2012 to 2013
$177k
NHLBI NIH HHS K99 HL106232NHLBI NIH HHS K99HL106232NHLBI NIH HHS R00 HL106232NHLBI NIH HHS R00HL106232NHLBI NIH HHS R01 HL105626NHLBI NIH HHS R01 HL105930NHLBI NIH HHS R01HL105930
6 · The paper itself

Abstract

background and purposePreliminary studies suggest that intracranial arteries are capable of accommodating plaque formation by remodeling. We sought to study the ability and extent of intracranial arteries to remodel using 3-dimensional high-resolution black blood magnetic resonance imaging and investigate its relation to ischemic events.

methodsForty-two patients with cerebrovascular ischemic events underwent 3-dimensional time-of-flight magnetic resonance angiography and contrast-enhanced black blood magnetic resonance imaging examinations at 3 T for intracranial atherosclerotic disease. Each plaque was classified by location (eg, posterior versus anterior circulation) and its likelihood to have caused a stroke identified on magnetic resonance imaging (culprit, indeterminate, or nonculprit). Lumen area, outer wall area, and wall area were measured at the lesion and reference sites. Plaque burden was calculated as wall area divided by outer wall area. The arterial remodeling ratio (RR) was calculated as outer wall area at the lesion site divided by outer wall area at the reference site after adjusting for vessel tapering. Arterial remodeling was categorized as positive if RR>1.05, intermediate if 0.95≤RR≤1.05, and negative if RR<0.95.

resultsOne hundred and thirty-seven plaques were identified in 42 patients (37% [50] posterior and 63% [87] anterior). Compared with anterior circulation plaques, posterior circulation plaques had a larger plaque burden (77.7±15.7 versus 69.0±14.0; P=0.008), higher RR (1.14±0.38 versus 0.95±0.32; P=0.002), and more often exhibited positive remodeling (54.0% versus29.9%; P=0.011). Positive remodeling was marginally associated with downstream stroke presence when adjusted for plaque burden (odds ratio 1.34, 95% confidence interval: 0.99-1.81).

conclusionsIntracranial arteries remodel in response to plaque formation, and posterior circulation arteries have a greater capacity for positive remodeling and, consequently, may more likely elude angiographic detection. Arterial remodeling may provide insight into stroke risk.

Indexed as

Vascular RemodelingAdultAgedCerebral ArteriesCohort StudiesConstriction, PathologicFemaleHumansImage Processing, Computer-AssistedIntracranial ArteriosclerosisMagnetic Resonance AngiographyMagnetic Resonance ImagingMaleMiddle AgedOrgan SizePlaque, Atheroscleroticatherosclerosisintracranial arteriosclerosisMRIstrokevascular remodeling

Identifiers

PMID26742795
PMCPMC4729583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.