Evidence map›Paper›PMID 26742732›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2016

Prostate cancer treated with image-guided helical TomoTherapy® and image-guided LINAC-IMRT : Correlation between high-dose bladder volume, margin reduction, and genitourinary toxicity.

Sonia Drozdz, Michael Schwedas, Henning Salz, Susan Foller, Thomas G Wendt

Abstract readComparative StudyControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Hydrogel injection reduces rectal toxicity after radiotherapy for localized prostate cancer.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sonia DrozdzDepartment of Radiation Oncology, University Hospital Jena, Friedrich-Schiller-University Jena, Bachstrasse 18, 07743, Jena, Germany. Sonia.Drozdz@med.uni-jena.de.
Michael SchwedasDepartment of Radiation Oncology, Section of Medical Physics, University Hospital Jena, Friedrich-Schiller-University Jena, Bachstrasse 18, 07743, Jena, Germany.
Henning SalzDepartment of Radiation Oncology, Section of Medical Physics, University Hospital Jena, Friedrich-Schiller-University Jena, Bachstrasse 18, 07743, Jena, Germany.
Susan FollerDepartment of Urology, University Hospital Jena, Friedrich-Schiller-University Jena, Lessingstrasse 1, 07743, Jena, Germany.
Thomas G WendtDepartment of Radiation Oncology, University Hospital Jena, Friedrich-Schiller-University Jena, Bachstrasse 18, 07743, Jena, Germany.
Friedrich Schiller University Jena · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe compared different image-guidance (IG) strategies for prostate cancer with high-precision IG intensity-modulated radiation therapy (IMRT) using TomoTherapy® (Accuray Inc., Madison, WI, USA) and linear accelerator (LINAC)-IMRT and their impact on planning target volume (PTV) margin reduction. Follow-up data showed reduced bladder toxicity in TomoTherapy patients compared to LINAC-IMRT. The purpose of this study was to quantify whether the treatment delivery technique and decreased margins affect reductions in bladder toxicity. PATIENTS AND

methodsSetup corrections from 30 patients treated with helical TomoTherapy and 30 treated with a LINAC were analyzed. These data were used to simulate three IG protocols based on setup error correction and a limited number of imaging sessions. For all patients, gastrointestinal (GI) and genitourinary (GU) toxicity was documented and correlated with the treatment delivery technique.

resultsFor fiducial marker (FM)-based RT, a margin reduction of up to 3.1, 3.0, and 4.8 mm in the left-right (LR), superior-inferior (SI), and anterior-posterior (AP) directions, respectively, could be achieved with calculation of a setup correction from the first three fractions and IG every second day. Although the bladder volume was treated with mean doses of 35 Gy in the TomoTherapy group vs. 22 Gy in the LINAC group, we observed less GU toxicity after TomoTherapy.

conclusionIntraprostate FMs allow for small safety margins, help decrease imaging frequency after setup correction, and minimize the dose to bladder and rectum, resulting in lower GU toxicity. In addition, IMRT delivered with TomoTherapy helps to avoid hotspots in the bladder neck, a critical anatomic structure associated with post-RT urinary toxicity.

Indexed as

AdenocarcinomaAgedAged, 80 and overCombined Modality TherapyGastrointestinal TractHumansMaleMiddle AgedNeoplasm GradingProstatic NeoplasmsRadiation InjuriesRadiosurgeryRadiotherapy DosageRadiotherapy, High-EnergyRadiotherapy, Intensity-ModulatedStatistics as TopicAdverse effectsFiducial markersMarginsOrgans at riskTomotherapy

Identifiers

PMID26742732
OpenAlexW2231510547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.