ArticleMolecular neurobiology2017
Guanosine Anxiolytic-Like Effect Involves Adenosinergic and Glutamatergic Neurotransmitter Systems.
Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 62 citations in OpenAlex.
- Guanosine Attenuates Astrocyte-Associated Glutamatergic Dysregulation and Improves Survival in Acute Liver Failure-Induced Hepatic Encephalopathy.Metabolites · 2026Article
- The impact of purine nucleosides on neuroplasticity in the adult brain.Purinergic signalling · 2025Review
- Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward a multimodal mechanism of action?Purinergic signalling · 2025Review
- Investigating the Impact of SN-38 on Mouse Brain Metabolism Based on Metabolomics.Drug design, development and therapy · 2024Article
- Adenosine signaling: a potential therapeutic target for psychogenic erectile dysfunction.American journal of translational research · 2024Review
- The antidepressant-like effect of guanosine involves the modulation of adenosine APurinergic signalling · 2023Article
- Influence of Guanine-Based Purines on the Oxidoreductive Reactions Involved in Normal or Altered Brain Functions.Journal of clinical medicine · 2023Review
- Purinergic signaling: A gatekeeper of blood-brain barrier permeation.Frontiers in pharmacology · 2023Review
- Effects of co-exposure to lead and manganese on learning and memory deficits.Journal of environmental sciences (China) · 2022Article
- Clozapine induces astrocyte-dependent FDG-PET hypometabolism.European journal of nuclear medicine and molecular imaging · 2022Article
- Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria.Frontiers in immunology · 2022Article
- Low doses of ketamine and guanosine abrogate corticosterone-induced anxiety-related behavior, but not disturbances in the hippocampal NLRP3 inflammasome pathway.Psychopharmacology · 2021Article
- Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice.Scientific reports · 2021Article
- Neuroprotective Effects of Guanosine in Ischemic Stroke-Small Steps towards Effective Therapy.International journal of molecular sciences · 2021Review
- Adenosine APurinergic signalling · 2021Article
- Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling.Purinergic signalling · 2021Article
- Effects of intranasal guanosine administration on brain function in a rat model of ischemic stroke.Purinergic signalling · 2021Article
- Guanosine Mechanisms of Action: Toward Molecular Targets.Frontiers in pharmacology · 2021Article
- Antidepressant-Like Effects of Chronic Guanosine in the Olfactory Bulbectomy Mouse Model.Frontiers in psychiatry · 2021Article
- Raising the Guanosine-Based Molecules as Regulators of Excitable Tissues by the Exosomal-Vehiculated Signaling.Frontiers in pharmacology · 2021Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidences indicate that endogenous modulators of excitatory synapses in the mammalian brain are potential targets for treating neuropsychiatric disorders. Indeed, glutamatergic and adenosinergic neurotransmissions were recently highlighted as potential targets for developing innovative anxiolytic drugs. Accordingly, it has been shown that guanine-based purines are able to modulate both adenosinergic and glutamatergic systems in mammalian central nervous system. Here, we aimed to investigate the potential anxiolytic-like effects of guanosine and its effects on the adenosinergic and glutamatergic systems. Acute/systemic guanosine administration (7.5 mg/kg) induced robust anxiolytic-like effects in three classical anxiety-related paradigms (elevated plus maze, light/dark box, and round open field tasks). These guanosine effects were correlated with an enhancement of adenosine and a decrement of glutamate levels in the cerebrospinal fluid. Additionally, pre-administration of caffeine (10 mg/kg), an unspecific adenosine receptors' antagonist, completely abolished the behavioral and partially prevented the neuromodulatory effects exerted by guanosine. Although the hippocampal glutamate uptake was not modulated by guanosine (both ex vivo and in vitro protocols), the synaptosomal K
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