ArticleeLife2016
Dendritic mitochondria reach stable positions during circuit development.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 98 citations in OpenAlex.
- Drosophila dendrites are resilient to adult-onset deficits in mitochondrial dynamics.The Journal of cell biology · 2026Article
- Mitochondrial molecular diversity in the brain.Current opinion in neurobiology · 2026Review
- DRP1 mutations associated with EMPF1 encephalopathy perturb the transcriptional profile and maturation of cortical neurons.Journal of neurodevelopmental disorders · 2026Article
- Modulation of Neuronal Mitochondrial Injury by Gualou Guizhi Decoction in a Mouse Ischemia-Reperfusion Model.Iranian journal of biotechnology · 2026Article
- The mitochondria-targeted peptide HDAP2 reduces mitochondrial loss and retinal ganglion cell degeneration after optic nerve injury.Neuroscience · 2026Article
- Nicotinamide counteracts Rotenone-induced mitochondrial and neuronal dysfunction in a translational early-life model.Scientific reports · 2026Article
- A role for Fis1 in dendritic development.Scientific reports · 2025Article
- Article
- Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity.Nature communications · 2025Article
- Decoding the complex journeys of RNAs along neurons.Nucleic acids research · 2025Article
- Mitochondria are positioned at dendritic branch induction sites, a process requiring rhotekin2 and syndapin I.Nature communications · 2025Article
- The multifaceted role of mitochondria in autism spectrum disorder.Molecular psychiatry · 2025Review
- Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons.bioRxiv : the preprint server for biology · 2025Article
- Mitochondrial network reorganization and transient expansion during oligodendrocyte generation.Nature communications · 2024Article
- Mitochondrial plasticity and synaptic plasticity crosstalk; in health and Alzheimer's disease.CNS neuroscience & therapeutics · 2024Review
- The Skin-Brain Axis: From UV and Pigmentation to Behaviour Modulation.International journal of molecular sciences · 2024Review
- Article
- VAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity.Nature communications · 2024Article
- Postsynaptic mitochondria are positioned to support functional diversity of dendritic spines.eLife · 2023Article
- Computational modeling of AMPK and mTOR crosstalk in glutamatergic synapse calcium signaling.NPJ systems biology and applications · 2023Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Mitochondria move throughout neuronal dendrites and localize to sites of energy demand. The prevailing view of dendritic mitochondria as highly motile organelles whose distribution is continually adjusted by neuronal activity via Ca(2+)-dependent arrests is based on observations in cultured neurons exposed to artificial stimuli. Here, we analyze the movements of mitochondria in ganglion cell dendrites in the intact retina. We find that whereas during development 30% of mitochondria are motile at any time, as dendrites mature, mitochondria all but stop moving and localize stably to synapses and branch points. Neither spontaneous nor sensory-evoked activity and Ca(2+) transients alter motility of dendritic mitochondria; and pathological hyperactivity in a mouse model of retinal degeneration elevates rather than reduces motility. Thus, our findings indicate that dendritic mitochondria reach stable positions during a critical developmental period of high motility, and challenge current views about the role of activity in regulating mitochondrial transport in dendrites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.