ArticlePLoS biology2016
Exosomes Mediate LTB4 Release during Neutrophil Chemotaxis.
Article in PLoS biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 81 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 156 citations in OpenAlex.
- Potential role of extracellular vesicles in bacterial phagocytosis during Escherichia coli pneumonia in ex vivo perfused human lungs.Intensive care medicine experimental · 2026Article
- Exosome-mediated chemotaxis optimizes leader-follower cell migration.PLoS computational biology · 2026Article
- Article
- Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI.bioRxiv : the preprint server for biology · 2025Article
- Exploring Exosome Contributions to Gouty Arthritis: A Proteomics and Experimental Study.International journal of molecular sciences · 2025Article
- Yersinia pestis Actively Inhibits the Production of Extracellular Vesicles by Human Neutrophils.Journal of extracellular vesicles · 2025Article
- Nuclear envelope budding: Getting large macromolecular complexes out of the nucleus.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Article
- The expanding family of neutrophil-derived extracellular vesicles.Immunological reviews · 2022Review
- Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling.Molecular metabolism · 2022Review
- Neutrophils discriminate live from dead bacteria by integrating signals initiated by Fprs and TLRs.The EMBO journal · 2022Article
- Extracellular Vesicles as Central Mediators of COPD Pathophysiology.Annual review of physiology · 2022Review
- LTB4 Promotes Acute Lung Injury via Upregulating the PLCDisease markers · 2022Article
- Neutrophil dysfunction in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2021Article
- Extracellular vesicles: mediators of intercellular communication in tissue injury and disease.Cell communication and signaling : CCS · 2021Review
- Small extracellular vesicle-mediated bidirectional crosstalk between neutrophils and tumor cells.Cytokine & growth factor reviews · 2021Review
- Signal integration in forward and reverse neutrophil migration: Fundamentals and emerging mechanisms.Current opinion in cell biology · 2021Review
- Retraction: Exosomes Mediate LTB4 Release during Neutrophil Chemotaxis.PLoS biology · 2021Article
- Exosomes mediate LTB4 release during neutrophil chemotaxis.PLoS biology · 2021Article
- A parasitoid wasp of Drosophila employs preemptive and reactive strategies to deplete its host's blood cells.PLoS pathogens · 2021Article
- The Neutrophil Secretome as a Crucial Link between Inflammation and Thrombosis.International journal of molecular sciences · 2021Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2021-07-07Falsification/Fabrication of Data · Falsification/Fabrication of Image · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · Retract and Replace · · see: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001271;
- Retracted
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Leukotriene B4 (LTB4) is secreted by chemotactic neutrophils, forming a secondary gradient that amplifies the reach of primary chemoattractants. This strategy increases the recruitment range for neutrophils and is important during inflammation. Here, we show that LTB4 and its synthesizing enzymes localize to intracellular multivesicular bodies that, upon stimulation, release their content as exosomes. Purified exosomes can activate resting neutrophils and elicit chemotactic activity in a LTB4 receptor-dependent manner. Inhibition of exosome release leads to loss of directional motility with concomitant loss of LTB4 release. Our findings establish that the exosomal pool of LTB4 acts in an autocrine fashion to sensitize neutrophils towards the primary chemoattractant, and in a paracrine fashion to mediate the recruitment of neighboring neutrophils in trans. We envision that this mechanism is used by other signals to foster communication between cells in harsh extracellular environments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.