Evidence map›Paper›PMID 26741791›Full record

ArticleACS nano2016

Ultrahigh (19)F Loaded Cu1.75S Nanoprobes for Simultaneous (19)F Magnetic Resonance Imaging and Photothermal Therapy.

Hongli Chen, Manli Song, Juan Tang, Gaofei Hu, Suying Xu, Zhide Guo, Nannan Li, Jiabin Cui, Xianzhong Zhang, Xiaoyuan Chen and 1 more

Abstract read
In one paragraph

Article in ACS nano, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Multifunctional Magnetic Resonance Imaging Probes.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  2. Review
  3. Review
  4. Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  5. Review
  6. ChemMedChem · 2022
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Fluorinated ZnFeACS omega · 2020
    Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hongli ChenState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.
Manli SongCenter for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University , Xiamen, Fujian 361005, People's Republic of China.
Juan TangState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.
Gaofei HuState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.
Suying XuState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.
Zhide GuoCenter for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University , Xiamen, Fujian 361005, People's Republic of China.
Nannan LiState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.
Jiabin CuiState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.
Xianzhong ZhangCenter for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University , Xiamen, Fujian 361005, People's Republic of China.
Xiaoyuan ChenLaboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
Leyu WangState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.

Funding

Laboratory of Molecular Imaging and NanomedicineZIAEB000073 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI CHEN, XIAOYUAN · 2010 to 2020
$32.8M
Intramural NIH HHS Z99 EB999999Intramural NIH HHS ZIA EB000073
6 · The paper itself

Abstract

(19)F magnetic resonance imaging (MRI) is a powerful noninvasive, sensitive, and accurate molecular imaging technique for early diagnosis of diseases. The major challenge of (19)F MRI is signal attenuation caused by the reduced solubility of probes with increased number of fluorine atoms and the restriction of molecular mobility. Herein, we present a versatile one-pot strategy for the fabrication of a multifunctional nanoprobe with high (19)F loading (∼2.0 × 10(8 19)F atoms per Cu1.75S nanoparticle). Due to the high (19)F loading and good molecular mobility that results from the small particle size (20.8 ± 2.0 nm) and ultrathin polymer coating, this nanoprobe demonstrates ultrahigh (19)F MRI signal. In vivo tests show that this multifunctional nanoprobe is suitable for (19)F MRI and photothermal therapy. This versatile fabrication strategy has also been readily extended to other single-particle nanoprobes for ablation and sensitive multimodal imaging.

Indexed as

AnimalsCell SurvivalContrast MediaCopperFemaleFluorine-19 Magnetic Resonance ImagingFluorine RadioisotopesHeLa CellsHumansInjections, SubcutaneousMammary Glands, AnimalMammary Neoplasms, ExperimentalMiceMice, Inbred BALB CNanoparticlesParticle SizeContrast MediaCoppercupric sulfideFluorine Radioisotopes19F MRIcopper sulfide nanoparticlemultifunctional nanoprobesphotothermal imaging and therapy

Identifiers

PMID26741791
PMCPMC5218586

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.