Evidence map›Paper›PMID 26741730›Full record

ArticleOrganic letters2016

Diastereoselective Synthesis of the Aminocyclitol Core of Jogyamycin via an Allene Aziridination Strategy.

Nels C Gerstner, Christopher S Adams, R David Grigg, Maik Tretbar, Jared W Rigoli, Jennifer M Schomaker

Abstract read
In one paragraph

Article in Organic letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Strategies for the Syntheses of Pactamycin and Jogyamycin.Angewandte Chemie (International ed. in English) · 2021
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nels C GerstnerDepartment of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States.
Christopher S AdamsDepartment of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States.
R David GriggDepartment of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States.
Maik TretbarDepartment of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States.
Jared W RigoliDepartment of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States.
Jennifer M SchomakerDepartment of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States.

Funding

Synthetic approaches to complex amines that inhibit protein synthesis by impacting the ribosomeR01GM111412 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SCHOMAKER, JENNIFER MARIE · 2014 to 2022
$2.4M
NMR SPECTROMETERS10RR008389 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI VEDEJS, EDWIN · 1993 to 1993
–
NCRR NIH HHS S10 RR008389NIGMS NIH HHS 1R01GM111412-01NIGMS NIH HHS R01 GM111412
6 · The paper itself

Abstract

Oxidative allene amination provides rapid access to densely functionalized amine-containing stereotriads through highly reactive bicyclic methyleneaziridine intermediates. This strategy has been demonstrated as a viable approach for the construction of the densely functionalized aminocyclitol core of jogyamycin, a natural product with potent antiprotozoal activity. Importantly, the flexibility of oxidative allene amination will enable the syntheses of modified aminocyclitol analogues of the jogyamycin core.

Indexed as

AlkadienesAminationAminesMolecular StructureOxidation-ReductionPactamycinStereoisomerismStreptomycesAlkadienesAminesjogyamycinPactamycinpropadiene

Identifiers

PMID26741730
PMCPMC4845904

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.