Trial reportJournal of perinatology : official journal of the California Perinatal Association2016
Using very high frequencies with very low lung volumes during high-frequency oscillatory ventilation to protect the immature lung. A pilot study.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- High-frequency oscillatory ventilation with volume guarantee in infants: a systematic review.Pediatric research · 2025Pooled it
- [Therapeutic efficacy of volume-guaranteed high frequency oscillation ventilation on respiratory failure in preterm infants with a gestational age of 28-34 weeks: a prospective randomized controlled study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Trial
- Temporal Dynamics and Clinical Relevance of Oscillatory Amplitude Variability During High-Frequency Oscillatory Ventilation With Volume Guarantee in Preterm Infants.Pediatric pulmonology · 2026Article
- Ventilatory efficiency during high-frequency oscillatory ventilation with volume guarantee in preterm infants.European journal of pediatrics · 2026Article
- Gas transport mechanisms during high-frequency ventilation.Respiratory research · 2024Review
- Volume Targeting During High-Frequency Oscillatory Ventilation: What Should Clinicians Know.Respiratory care · 2024Article
- Impact on cerebral hemodynamics of the use of volume guarantee combined with high frequency oscillatory ventilation in a neonatal animal respiratory distress model.European journal of pediatrics · 2024Article
- High-frequency ventilation in preterm infants and neonates.Pediatric research · 2023Review
- Effects of High-Frequency Oscillatory Ventilation With Volume Guarantee During Surfactant Treatment in Extremely Low Gestational Age Newborns With Respiratory Distress Syndrome: An Observational Study.Frontiers in pediatrics · 2021Article
- Effect of a new respiratory care bundle on bronchopulmonary dysplasia in preterm neonates.European journal of pediatrics · 2020Observational
- DCOEuropean journal of pediatrics · 2020Article
- Volume Guarantee High-Frequency Oscillatory Ventilation in Preterm Infants With RDS: Tidal Volume and DCOFrontiers in pediatrics · 2020Article
- Effect of high-frequency oscillatory ventilation combined with volume guarantee on preterm infants with hypoxic respiratory failure.Journal of the Chinese Medical Association : JCMA · 2019Article
- Effective Tidal Volume for Normocapnia in Very-Low-Birth-Weight Infants Using High-Frequency Oscillatory Ventilation.Yonsei medical journal · 2018Article
- Effect of frequency on pressure cost of ventilation and gas exchange in newborns receiving high-frequency oscillatory ventilation.Pediatric research · 2017Article
- Response to "Targeting supernormal frequencies and very low tidal volumes in high-frequency oscillatory ventilation: can 'volume guarantee' deliver?".Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Targeting supernormal frequencies and very low tidal volumes in high-frequency oscillatory ventilation: can 'volume guarantee' deliver?Journal of perinatology : official journal of the California Perinatal Association · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHigh-frequency oscillatory ventilation (HFOV) has been described as a rescue therapy in severe respiratory distress syndrome (RDS) with a potential protective effect in immature lungs. In recent times, HFOV combined with the use of volume guarantee (VG) strategy has demonstrated an independent effect of the frequency on tidal volume to increase carbon-dioxide (CO2) elimination. The aim of this study was to demonstrate the feasibility of using the lowest tidal volume on HFOV+VG to prevent lung damage, maintaining a constant CO2 elimination by increasing the frequency. STUDY
designNewborn infants with RDS on HFOV were prospectively included. After adequate and stable ventilation using a standard HFOV strategy, the tidal volume was fixed using VG and decreased while the frequency was increased to the highest possible to maintain a constant CO2 elimination. Pre- and post-PCO2, delta pressure and tidal volume obtained in each situation were compared.
resultTwenty-three newborn infants were included. It was possible to increase the frequency while decreasing the tidal volume in all patients, maintaining a similar CO2 elimination, with a tendency to a lower mean PCO2 after reaching the highest frequency. High-frequency tidal volume was significantly lower, 2.20 ml kg(-1) before vs 1.59 ml kg(-1) at the highest frequency.
conclusionIt is possible to use lower delivered tidal volumes during HFOV combined with VG and higher frequencies with adequate ventilation to allow minimizing lung injury.
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