Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03211013 (Placebo-Controlled Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD), which is not on this map. Cited by 72 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Placebo-Controlled Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD
Who cites it
72 citing papers in PubMed, 4 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Common alterations of whole and subregion-specific amygdala intrinsic functional connectivity across psychiatric disorders: a meta-analysis.Molecular psychiatry · 2026Pooled it
- Exploring the efficacy of intranasal oxytocin (OXT) for anxiety and stress-related disorders through functional magnetic resonance imaging (fMRI) study: a systematic review.BMC pharmacology & toxicology · 2025Pooled it
- Functional brain changes after alternative pharmacological interventions in posttraumatic stress disorder: A systematic review of clinical trials.Brain and behavior · 2023Pooled it
- The effect of intranasal oxytocin on neural response to facial emotions in healthy adults as measured by functional MRI: A systematic review.Psychiatry research. Neuroimaging · 2018Pooled it
- Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top-Down Middle Cingulate Amygdala Regulation and Brain-Wide Fear Representations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Trial
- Effects of intranasal oxytocin on fear extinction learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Connectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin.Molecular psychiatry · 2024Trial
- Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women.Translational psychiatry · 2023Trial
- Oxytocinergic Modulation of Stress-Associated Amygdala-Hippocampus Pathways in Humans Is Mediated by Serotonergic Mechanisms.The international journal of neuropsychopharmacology · 2022Trial
- Effects of oxytocin administration on fear-potentiated acoustic startle in co-occurring PTSD and alcohol use disorder: A randomized clinical trial.Psychiatry research · 2022Trial
- Effects of intranasal oxytocin on threat- and reward-related functional connectivity in men and women with and without childhood abuse-related PTSD.Psychiatry research. Neuroimaging · 2021Trial
- Oxytocin, PTSD, and sexual abuse are associated with attention network intrinsic functional connectivity.Psychiatry research. Neuroimaging · 2021Trial
- In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing.Translational psychiatry · 2021Trial
- Oxytocin modulates local topography of human functional connectome in healthy men at rest.Communications biology · 2021Trial
- Oxytocin induces long-lasting adaptations within amygdala circuitry in autism: a treatment-mechanism study with randomized placebo-controlled design.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Oxytocin Enhances an Amygdala Circuit Associated With Negative Symptoms in Schizophrenia: A Single-Dose, Placebo-Controlled, Crossover, Randomized Control Trial.Schizophrenia bulletin · 2020Trial
- Augmenting Prolonged Exposure therapy for PTSD with intranasal oxytocin: A randomized, placebo-controlled pilot trial.Journal of psychiatric research · 2018Trial
- Intranasal Oxytocin Selectively Modulates Large-Scale Brain Networks in Humans.Brain connectivity · 2017Trial
- Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women.Translational psychiatry · 2017Trial
- A Preliminary Examination of Endogenous Peripheral Oxytocin in a Pilot Randomized Clinical Trial of Oxytocin-Enhanced Psychotherapy for Posttraumatic Stress Disorder.Journal of clinical psychopharmacologyTrial
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuropeptide oxytocin (OT) has been suggested as a promising pharmacological agent for medication-enhanced psychotherapy in posttraumatic stress disorder (PTSD) because of its anxiolytic and prosocial properties. We therefore investigated the behavioral and neurobiological effects of a single intranasal OT administration (40 IU) in PTSD patients. We conducted a randomized, placebo-controlled, cross-over resting-state fMRI study in male and female police officers with (n=37, 21 males) and without PTSD (n=40, 20 males). We investigated OT administration effects on subjective anxiety and functional connectivity of basolateral (BLA) and centromedial (CeM) amygdala subregions with prefrontal and salience processing areas. In PTSD patients, OT administration resulted in decreased subjective anxiety and nervousness. Under placebo, male PTSD patients showed diminished right CeM to left ventromedial prefrontal cortex (vmPFC) connectivity compared with male trauma-exposed controls, which was reinstated after OT administration. Additionally, female PTSD patients showed enhanced right BLA to bilateral dorsal anterior cingulate cortex (dACC) connectivity compared with female trauma-exposed controls, which was dampened after OT administration. Although caution is warranted, our findings tentatively suggest that OT has the potential to diminish anxiety and fear expression of the amygdala in PTSD, either via increased control of the vmPFC over the CeM (males) or via decreased salience processing of the dACC and BLA (females). Our findings add to accumulating evidence that OT administration could potentially enhance treatment response in PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.