ArticlePloS one2016
Honey Bee Allatostatins Target Galanin/Somatostatin-Like Receptors and Modulate Learning: A Conserved Function?
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- Contrasting whole-genome diversity patterns and adaptation in honeybees from two southern European glacial refugia.iScience · 2026Article
- Chronic Larval Exposure to Lambda-Cyhalothrin Alters Gene Expression in Both Larval and Adult Honey Bees (Insects · 2025Article
- Allatostatin-C signaling in the crab Carcinus maenas is implicated in the ecdysis program.The Journal of experimental biology · 2025Article
- Somatostatin Receptor Gene Functions in Growth Regulation in Bivalve Scallop and Clam.International journal of molecular sciences · 2024Article
- Reduction of stress responses in honey bees by synthetic ligands targeting an allatostatin receptor.Scientific reports · 2022Article
- Allatostatin A Signalling: Progress and New Challenges From a Paradigmatic Pleiotropic Invertebrate Neuropeptide Family.Frontiers in physiology · 2022Review
- Does Differential Receptor Distribution Underlie Variable Responses to a Neuropeptide in the Lobster Cardiac System?International journal of molecular sciences · 2021Article
- Molecular and functional characterization of somatostatin-type signalling in a deuterostome invertebrate.Open biology · 2020Article
- Identification, Localization in the Central Nervous System and Novel Myostimulatory Effect of Allatostatins inInternational journal of molecular sciences · 2020Article
- Probing the Honey Bee Diet-Microbiota-Host Axis Using Pollen Restriction and Organic Acid Feeding.Insects · 2020Article
- Role of Oxytocin/Vasopressin-Like Peptide and Its Receptor in Vitellogenesis of Mud Crab.International journal of molecular sciences · 2020Article
- Changes in responsiveness to allatostatin treatment accompany shifts in stress reactivity in young worker honey bees.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
- Article
- Three members of a peptide family are differentially distributed and elicit differential state-dependent responses in a pattern generator-effector system.Journal of neurophysiology · 2018Article
- C-type allatostatins mimic stress-related effects of alarm pheromone on honey bee learning and memory recall.PloS one · 2017Article
- Neuropharmacological Manipulation of Restrained and Free-flying Honey Bees, Apis mellifera.Journal of visualized experiments : JoVE · 2016Article
- Sarcoptes scabiei: genomics to proteomics to biology.Parasites & vectors · 2016Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sequencing of the honeybee genome revealed many neuropeptides and putative neuropeptide receptors, yet functional characterization of these peptidic systems is scarce. In this study, we focus on allatostatins, which were first identified as inhibitors of juvenile hormone synthesis, but whose role in the adult honey bee (Apis mellifera) brain remains to be determined. We characterize the bee allatostatin system, represented by two families: allatostatin A (Apime-ASTA) and its receptor (Apime-ASTA-R); and C-type allatostatins (Apime-ASTC and Apime-ASTCC) and their common receptor (Apime-ASTC-R). Apime-ASTA-R and Apime-ASTC-R are the receptors in bees most closely related to vertebrate galanin and somatostatin receptors, respectively. We examine the functional properties of the two honeybee receptors and show that they are transcriptionally expressed in the adult brain, including in brain centers known to be important for learning and memory processes. Thus we investigated the effects of exogenously applied allatostatins on appetitive olfactory learning in the bee. Our results show that allatostatins modulate learning in this insect, and provide important insights into the evolution of somatostatin/allatostatin signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.