Evidence map›Paper›PMID 26740973›Full record

ArticleReview course lectures : presented at the ... Clinical and Scientific Congress of the International Anesthesia Research Society2012

Genomic Medicine: Why Do "Similar" Patients Have Different Outcomes?

Debra Schwinn, Maren Kleine-Brueggeney, Anush Oganesian

Abstract read
In one paragraph

Article in Review course lectures : presented at the ... Clinical and Scientific Congress of the International Anesthesia Research Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Debra SchwinnDepartment of Anesthesiology & Pain Medicine, Allan J. Treuer Endowed Professor, Adjunct Professor of Pharmacology and Genome Sciences, Box 356540, University of Washington, Seattle, WA 98195-6540, 206-543-2673, dschwinn@uw.edu.
Maren Kleine-BrueggeneyUniversity of Washington, Resident, Department of Anesthesiology & Pain Therapy, Bern, Switzerland, Department of Anesthesiology & Pain Medicine, Box 356540, University of Washington, Seattle, WA 98195-6540, 206-685-7968, marenkb@uw.edu.
Anush OganesianDepartment of Anesthesiology & Pain Medicine, Box 356540, University of Washington, Seattle, WA 98195-6540, 206-685-7520, anush@uw.edu.
University of Washington · US

Funding

Subcellular Distribution &Regulation of ala-AdrenoceptoR37HL049103 · NHLBI · UNIVERSITY OF WASHINGTON · PI SCHWINN, DEBRA ANNE · 2005 to 2014
$3.9M
MOLECULAR DISTRIBUTION OF HUMAN ADRENERGIC RECEPTORSR01HL049103 · NHLBI · DUKE UNIVERSITY · PI SCHWINN, DEBRA A. · 1993 to 2003
$1.4M
NHLBI NIH HHS R01 HL049103NHLBI NIH HHS R37 HL049103
6 · The paper itself

Abstract

Genomic variation is an important factor in why supposedly "similar" patients react differently to drugs, have different disease course(s), and varying clinical outcomes. This review provides an update on concepts in modern genomic medicine with an emphasis on clinically relevant study approaches, disease/drug pathway analysis, and recent pharmacogenomic findings. The application of genomic medicine and its importance for rapid diagnosis of disease-causing agents, as well as its clinical application in human disease diagnosis/treatment and in cardiovascular disease are discussed. In addition to direct clinical applications, modern genomic approaches also play an important role in elucidating new mechanisms of disease. Finally, the role of the National Institutes of Health national pharmacogenomics research network in codifying "bench to bedside" translation of genetic results that impact drug therapy will also be discussed.

Identifiers

PMID26740973
PMCPMC4699320
OpenAlexW2108953804

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.