SynthesisNeuroImage. Clinical2015
Relationship between chronic pain and brain reorganization after deafferentation: A systematic review of functional MRI findings.
Synthesis in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Neural correlates of phantom motor execution: A functional neuroimaging systematic review and meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Pooled it
- Evaluation of Central Sensitisation in Bladder Pain Syndrome: A Systematic Review.International urogynecology journal · 2024Pooled it
- Disentangling the Effects of Spinal Cord Injury and Related Neuropathic Pain on Supraspinal Neuroplasticity: A Systematic Review on Neuroimaging.Frontiers in neurology · 2019Pooled it
- The Effects of Low-Dose Esketamine Combined with Paravertebral Block on Postoperative Hyperalgesia and Enhanced Recovery in Non-Intubated Video-Assisted Thoracic Surgery: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Distinguishing the activity of adjacent somatosensory nuclei within the brainstem using 3T fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Effects of rTMS over the contralateral M1 combined with NMES on pain and functional mobility in primary frozen shoulder: study protocol for a 4-week double-blind, randomized, sham-controlled trial.Frontiers in neurology · 2025Article
- Immersive virtual reality for chronic neuropathic pain after spinal cord injury: a pilot, randomized, controlled trial.Pain reports · 2024Article
- Clinical Characteristics Associated with the PLP-PLS Index, a New Potential Metric to Phenotype Phantom Limb Pain.Biomedicines · 2024Article
- Early versus delayed lower extremity amputations caused by firearm injury: A minimum 2-year follow-up.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2024Article
- An Innovative EEG-Based Pain Identification and Quantification: A Pilot Study.Sensors (Basel, Switzerland) · 2024Article
- Is Phantom Limb Awareness Necessary for the Treatment of Phantom Limb Pain?Neurologia medico-chirurgica · 2024Review
- Evolving techniques for reducing phantom limb pain.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Bibliometric Analysis of Functional Magnetic Resonance Imaging Studies on Manual Therapy Analgesia from 2002-2022.Journal of pain research · 2023Review
- Central Neuropathic Pain Syndromes: Current and Emerging Pharmacological Strategies.CNS drugs · 2022Review
- Unveiling the phantom: What neuroimaging has taught us about phantom limb pain.Brain and behavior · 2022Review
- Identifying Body Awareness-Related Brain Network Changes After Cognitive Multisensory Rehabilitation for Neuropathic Pain Relief in Adults With Spinal Cord Injury: Protocol of a Phase I Randomized Controlled Trial.Topics in spinal cord injury rehabilitation · 2022Article
- Mechanical Pain Sensitivity in Postamputation Pain.The Clinical journal of pain · 2021Article
- Plastic Changes in Pain and Motor Network Induced by Chronic Burn Pain.Journal of clinical medicine · 2021Article
- Development of a Phantom Limb Pain Model in Rats: Behavioral and Histochemical Evaluation.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Cortical plasticity in phantom limb pain: A fMRI study on the neural correlates of behavioral clinical manifestations.Psychiatry research. Neuroimaging · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMechanisms underlying the development of phantom limb pain and neuropathic pain after limb amputation and spinal cord injury, respectively, are poorly understood. The goal of this systematic review was to assess the robustness of evidence in support of "maladaptive plasticity" emerging from applications of advanced functional magnetic resonance imaging (MRI).
methodsUsing MeSH heading search terms in PubMed and SCOPUS, a systematic review was performed querying published manuscripts.
resultsFrom 146 candidate publications, 10 were identified as meeting the inclusion criteria. Results from fMRI investigations provided some level of support for maladaptive cortical plasticity, including longitudinal studies that demonstrated a change in functional organization related to decreases in pain. However, a number of studies have reported no relationship between reorganization, pain and deafferentation, and emerging evidence has also suggested the opposite - that is, chronic pain is associated with preserved cortical function.
conclusionBased solely on advanced functional neuroimaging results, there is only limited evidence for a relationship between chronic pain intensity and reorganization after deafferentation. The review demonstrates the need for additional neuroimaging studies to clarify the relationship between chronic pain and reorganization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.