ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Previous Ketamine Produces an Enduring Blockade of Neurochemical and Behavioral Effects of Uncontrollable Stress.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 82 citations in OpenAlex.
- Prophylactic (R,S)-Ketamine and (2S,6S)-Hydroxynorketamine Decrease Fear Expression by Differentially Modulating Fear Neural Ensembles.Biological psychiatry · 2025Article
- Mothering matters: Towards a better understanding of disrupted infant-caregiver relationships in both mother and offspring.Neurobiology of stress · 2025Review
- TargetingInternational journal of molecular sciences · 2024Review
- Multiple Sex- and Circuit-Specific Mechanisms Underlie Exercise-Induced Stress Resistance.Current topics in behavioral neurosciences · 2024Review
- A randomized pilot study of the prophylactic effect of ketamine on laboratory-induced stress in healthy adults.Neurobiology of stress · 2023Article
- From helplessness to controllability: toward a neuroscience of resilience.Frontiers in psychiatry · 2023Review
- Dose-dependent effects of esketamine on brain activity in awake mice: A BOLD phMRI study.Pharmacology research & perspectives · 2022Article
- The role of BDNF in mediating the prophylactic effects of (R,S)-ketamine on fear generalization and extinction.Translational psychiatry · 2022Article
- Physical Exercise Prevented Stress-Induced Anxiety via Improving Brain RNA Methylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Prophylactic (R,S)-Ketamine Is Effective Against Stress-Induced Behaviors in Adolescent but Not Aged Mice.The international journal of neuropsychopharmacology · 2022Article
- Ketamine as a prophylactic resilience-enhancing agent.Frontiers in psychiatry · 2022Review
- A Computational Model of Hopelessness and Active-Escape Bias in Suicidality.Computational psychiatry (Cambridge, Mass.) · 2022Article
- Acute (Frontiers in neuroscience · 2022Article
- Effect of ketamine on the physiological responses to combined hypoglycemic and psychophysical stress.IBRO neuroscience reports · 2021Article
- Role of Basolateral Amygdalar Somatostatin 2 Receptors in a Rat Model of Chronic Anxiety.Neuroscience · 2021Article
- Fluoroethylnormemantine, a Novel NMDA Receptor Antagonist, for the Prevention and Treatment of Stress-Induced Maladaptive Behavior.Biological psychiatry · 2021Article
- Fluoroethylnormemantine, A Novel Derivative of Memantine, Facilitates Extinction Learning Without Sensorimotor Deficits.The international journal of neuropsychopharmacology · 2021Article
- Intra-prefrontal cyclosporine potentiates ketamine-induced fear extinction in rats.Experimental brain research · 2021Article
- Impact of impaired glucose metabolism on responses to a psychophysical stressor: modulation by ketamine.Psychopharmacology · 2021Article
- Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions.Molecular psychiatry · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Recent interest in the antidepressant and anti-stress effects of subanesthetic doses of ketamine, an NMDA receptor antagonist, has identified mechanisms whereby ketamine reverses the effect of stress, but little is known regarding the prophylactic effect ketamine might have on future stressors. Here we investigate the prophylactic effect of ketamine against neurochemical and behavioral changes that follow inescapable, uncontrollable tail shocks (ISs) in Sprague Dawley rats. IS induces increased anxiety, which is dependent on activation of serotonergic (5-HT) dorsal raphe nucleus (DRN) neurons that project to the basolateral amygdala (BLA). Ketamine (10 mg/kg, i.p.) administered 2 h, 1 week, or 2 weeks before IS prevented the increased extracellular levels of 5-HT in the BLA typically produced by IS. In addition, ketamine administered at these time points blocked the decreased juvenile social investigation produced by IS. Microinjection of ketamine into the prelimbic (PL) region of the medial prefrontal cortex duplicated the effects of systemic ketamine, and, conversely, systemic ketamine effects were prevented by pharmacological inhibition of the PL. Although IS does not activate DRN-projecting neurons from the PL, IS did so after ketamine, suggesting that the prophylactic effect of ketamine is a result of altered functioning of this projection. SIGNIFICANCE STATEMENT: The reported data show that systemic ketamine, given up to 2 weeks before a stressor, blunts behavioral and neurochemical effects of the stressor. The study also advances understanding of the mechanisms involved and suggests that ketamine acts at the prelimbic cortex to sensitize neurons that project to and inhibit the DRN.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.