ArticleDiabetes2016
Proximity to Delivery Alters Insulin Sensitivity and Glucose Metabolism in Pregnant Mice.
Article in Diabetes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 43 citations in OpenAlex.
- A high-fat, high-sugar diet impairs maternal metabolism throughout pregnancy and lactation in mice.The Journal of physiology · 2026Article
- Distinct macronutrient ratios optimize offspring survival, growth, and maternal glucose tolerance across mouse reproduction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Meteorin-like controls metabolic adaptations and physiological myocardial remodeling in pregnancy and lactation.Frontiers in endocrinology · 2026Article
- Placental endocrine function is controlled by maternal gut Bifidobacterium in germ-free mice.Journal of translational medicine · 2025Article
- Pregnancy and a high-fat, high-sugar diet each attenuate mechanosensitivity of murine gastric vagal afferents, with no additive effects.The Journal of physiology · 2025Article
- GDF15 Knockout Does Not Substantially Impact Perinatal Body Weight or Neonatal Outcomes in Mice.Endocrinology · 2024Article
- A genetically small fetus impairs placental adaptations near term.Disease models & mechanisms · 2024Article
- GDF15 knockout does not substantially impact perinatal body weight or neonatal outcomes in mice.bioRxiv : the preprint server for biology · 2024Article
- Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations.Cellular and molecular life sciences : CMLS · 2024Article
- Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene.Cell metabolism · 2023Article
- Gestational Diabetes Mellitus and Antenatal Corticosteroid Therapy-A Narrative Review of Fetal and Neonatal Outcomes.Journal of clinical medicine · 2022Review
- Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice.Cellular and molecular life sciences : CMLS · 2022Article
- Identification of Structural and Molecular Signatures Mediating Adaptive Changes in the Mouse Kidney in Response to Pregnancy.International journal of molecular sciences · 2022Article
- The intestine and the microbiota in maternal glucose homeostasis during pregnancy.The Journal of endocrinology · 2022Review
- A mouse model of gestational diabetes shows dysregulated lipid metabolism post-weaning, after return to euglycaemia.Nutrition & diabetes · 2022Article
- Article
- Ablation of PI3K-p110alpha Impairs Maternal Metabolic Adaptations to Pregnancy.Frontiers in cell and developmental biology · 2022Article
- Loss of imprinting of the Igf2-H19 ICR1 enhances placental endocrine capacity via sex-specific alterations in signalling pathways in the mouse.Development (Cambridge, England) · 2022Article
- Reduction of litter size during lactation in rats greatly influences fatty acid profiles in dams.Journal of physiology and biochemistry · 2021Article
- Exploring the causes and consequences of maternal metabolic maladaptations during pregnancy: Lessons from animal models.Placenta · 2020Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
In late pregnancy, maternal insulin resistance occurs to support fetal growth, but little is known about insulin-glucose dynamics close to delivery. This study measured insulin sensitivity in mice in late pregnancy at day 16 (D16) and near term at D19. Nonpregnant (NP) and pregnant mice were assessed for metabolite and hormone concentrations, body composition by DEXA, tissue insulin signaling protein abundance by Western blotting, glucose tolerance and utilization, and insulin sensitivity using acute insulin administration and hyperinsulinemic-euglycemic clamps with [(3)H]glucose infusion. Whole-body insulin resistance occurred in D16 pregnant dams in association with basal hyperinsulinemia, insulin-resistant endogenous glucose production, and downregulation of several proteins in hepatic and skeletal muscle insulin signaling pathways relative to NP and D19 values. Insulin resistance was less pronounced at D19, with restoration of NP insulin concentrations, improved hepatic insulin sensitivity, and increased abundance of hepatic insulin signaling proteins. At D16, insulin resistance at whole-body, tissue, and molecular levels will favor fetal glucose acquisition, while improved D19 hepatic insulin sensitivity will conserve glucose for maternal use in anticipation of lactation. Tissue sensitivity to insulin, therefore, alters differentially with proximity to delivery in pregnant mice, with implications for human and other species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.