ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016
Persistent Infections by Nontyphoidal Salmonella in Humans: Epidemiology and Genetics.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 116 citations in OpenAlex.
- Detection and Characterization of Salmonella enterica Serotypes by Simple PCR Technologies.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Host-microbiota-pathogen interactions drive Salmonella enterica serovar Typhimurium pathogenesis.Nature reviews. Microbiology · 2026Review
- Comprehensive analyses of pathogen loads and immune responses alongside the gastrointestinal tract upon long-term Salmonella Typhimurium-infection of clinically resistant mice.European journal of microbiology & immunology · 2026Article
- Efficacy of a Salmonella Bacteriophage Cocktail Against Multidrug-Resistant Salmonella Isolates From Clinical and Food Samples.Health science reports · 2026Article
- Antibiotic Resistance Trends and Prescribing Patterns in Pediatric Non-TyphoidalInfection and drug resistance · 2026Article
- Persistence of non-typhoidalFrontiers in microbiology · 2026Review
- Solid-phase enrichment uncovers a hiddenFrontiers in public health · 2026Article
- Potentially Zoonotic Bacteria in Exotic Freshwater Turtles from the Canary Islands (Spain).Biology · 2025Article
- Genetic diversity ofGut microbes · 2025Article
- Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice.Nature microbiology · 2025Article
- Salmonella-superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state.The Journal of experimental medicine · 2025Article
- Emergence of carbapenem-resistantMicrobiology spectrum · 2025Article
- Risk factors associated with long-term shedding infections of non-typhoidal Salmonella in humans.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Disruption of sulfur transferase complex increases bacterial intramacrophage persistence.PLoS pathogens · 2025Article
- A multi-country outbreak ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Case Report: A case ofFrontiers in medicine · 2025Article
- Foodborne Infections andVaccines · 2024Review
- Article
- Shedding of nontyphoidalJournal of clinical microbiology · 2024Article
- Outbreak-associatedJournal of clinical microbiology · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byReply to Yue.2016
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAlthough chronic infections by typhoidal Salmonella are well-known, prolonged human infections by nontyphoidal Salmonella (NTS) are poorly characterized.
methodsWe retrospectively analyzed 48 345 culture-confirmed NTS infections that occurred in Israel 1995-2012. A case-control study was performed to identify risk factors associated with persistent infections. Whole-genome-sequencing, pulsed-field gel electrophoresis (PFGE), and a mouse infection model were used to study genetic and phenotypic differences between same-patient persistent, recurring isolates.
resultsIn total, 1047 cases of persistent NTS infections, comprising 2.2% of all reported cases of salmonellosis, were identified. The persistence periods ranged between 30 days to 8.3 years. The majority (93%) of the persistently infected patients were immunocompetent, and 65% were symptomatic with relapsing diarrhea, indicating a distinct clinical manifestation from the asymptomatic carriage of typhoidal Salmonella. Four NTS serovars (Mbandaka, Bredeney, Infantis and Virchow) were found to be significantly more frequently associated with persistence than others. Comparative genomics between early and later isolates obtained from the same patients confirmed clonal infection and showed 0 to 10 SNPs between persistent isolates. A different composition of mobile genetic elements (plasmids and phages) or amino acid substitutions in global regulators was identified in multiple cases. These changes resulted in differences in phenotype and virulence between early and later same-patient isolates.
conclusionsThese results illuminate the overlooked clinical manifestation of persistent salmonellosis that can serve as a human reservoir for NTS infections. Additionally, we demonstrate mechanisms of in-host microevolution and exhibit their potential to shape Salmonella pathogenicity, antimicrobial resistance and host-pathogen interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.