Evidence map›Paper›PMID 26740305›Full record

ArticleDepression and anxiety2016

PTSD SYMPTOMS ACROSS PREGNANCY AND EARLY POSTPARTUM AMONG WOMEN WITH LIFETIME PTSD DIAGNOSIS.

Maria Muzik, Ellen W McGinnis, Erika Bocknek, Diana Morelen, Katherine L Rosenblum, Israel Liberzon, Julia Seng, James L Abelson

Open access · bronzeAbstract read
In one paragraph

Article in Depression and anxiety, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Peripartum Depression: What's New?Current psychiatry reports · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maria MuzikDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Ellen W McGinnisDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Erika BocknekDepartment of Education, Wayne State University, Detroit, Michigan.
Diana MorelenDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Katherine L RosenblumDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Israel LiberzonDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Julia SengDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
James L AbelsonDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
University of Michigan–Ann Arbor · USWayne State University · US

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Michigan Mentored Clinical Scholars ProgramK12RR017607 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHTEINGART, DAVID EDUARDO · 2003 to 2007
$3.0M
PSYCHOBIOLOGY OF PTSD &ADVERSE OUTCOMES OF CHILDBEARINGR01NR008767 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SENG, JULIA S · 2005 to 2008
$2.1M
Infant Stress Response: Effects of Maternal PTSD and Infant GenesK23MH080147 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MUZIK, MARIA · 2008 to 2011
$717k
NCATS NIH HHS UL1 TR000433NCRR NIH HHS K12 RR017607NIMH NIH HHS K23 MH080147NINR NIH HHS R01 NR008767
6 · The paper itself

Abstract

backgroundLittle is known about trajectories of PTSD symptoms across the peripartum period in women with trauma histories, specifically those who met lifetime PTSD diagnoses prior to pregnancy. The present study seeks to identify factors that influence PTSD symptom load across pregnancy and early postpartum, and study its impact on postpartum adaptation.

methodThe current study is a secondary analysis on pregnant women with a Lifetime PTSD diagnosis (N = 319) derived from a larger community sample who were interviewed twice across pregnancy (28 and 35 weeks) and again at 6 weeks postpartum, assessing socioeconomic risks, mental health, past and ongoing trauma exposure, and adaptation to postpartum.

resultsUsing trajectory analysis, first we examined the natural course of PTSD symptoms based on patterns across peripartum, and found four distinct trajectory groups. Second, we explored factors (demographic, historical, and gestational) that shape the PTSD symptom trajectories, and examined the impact of trajectory membership on maternal postpartum adaptation. We found that child abuse history, demographic risk, and lifetime PTSD symptom count increased pregnancy-onset PTSD risk, whereas gestational PTSD symptom trajectory was best predicted by interim trauma and labor anxiety. Women with the greatest PTSD symptom rise during pregnancy were most likely to suffer postpartum depression and reported greatest bonding impairment with their infants at 6 weeks postpartum.

conclusionsScreening for modifiable risks (interpersonal trauma exposure and labor anxiety) and /or PTSD symptom load during pregnancy appears critical to promote maternal wellbeing.

Indexed as

Adaptation, PsychologicalAdultComorbidityFemaleHumansPregnancyPregnancy ComplicationsPuerperal DisordersSocioeconomic FactorsStress Disorders, Post-Traumaticdepressionmaternal childpregnancy and postpartumPTSDtrauma

Identifiers

PMID26740305
PMCPMC4930405
OpenAlexW2224336364

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.