Evidence map›Paper›PMID 26740292›Full record

ArticleJournal of periodontal research2016

The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease.

G M G Lima, B J M Corazza, R M Moraes, F E de Oliveira, L D de Oliveira, G C N Franco, D S Perrien, F Elefteriou, A L Anbinder

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

G M G LimaDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology of São José dos Campos, Univ Estadual Paulista - UNESP, São José dos Campos, SP, Brazil.
B J M CorazzaDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology of São José dos Campos, Univ Estadual Paulista - UNESP, São José dos Campos, SP, Brazil.
R M MoraesDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology of São José dos Campos, Univ Estadual Paulista - UNESP, São José dos Campos, SP, Brazil.
F E de OliveiraDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology of São José dos Campos, Univ Estadual Paulista - UNESP, São José dos Campos, SP, Brazil.
L D de OliveiraDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology of São José dos Campos, Univ Estadual Paulista - UNESP, São José dos Campos, SP, Brazil.
G C N FrancoDepartment of General Biology, State University of Ponta Grossa - UEPG, Ponta Grossa, Paraná, Brazil.
D S PerrienVanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
F ElefteriouVanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
A L AnbinderDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology of São José dos Campos, Univ Estadual Paulista - UNESP, São José dos Campos, SP, Brazil.
Universidade Estadual Paulista (Unesp) · BRVanderbilt University Medical Center · USIn-Q-Tel · USUniversidade Estadual de Ponta Grossa · BR

Funding

Novel ultrahigh resolution microCT imaging systemS10RR027631 · NCRR · VANDERBILT UNIVERSITY · PI PERRIEN, DANIEL S · 2010 to 2010
$460k
Interventions and Mechanisms of Disuse OsteopeniaIK2BX001634 · VA · VETERANS HEALTH ADMINISTRATION · PI PERRIEN, DANIEL S · 2013 to 2015
–
BLRD VA IK2 BX001634NCRR NIH HHS S10 RR027631
6 · The paper itself

Abstract

BACKGROUND AND

objectiveLP533401 is an inhibitor of tryptophan hydroxylase 1, which regulates serotonin production in the gut. Previous work indicates that LP533401 has an anabolic effect in bone. Thus, we hypothesized that inhibition of gut serotonin production may modulate the host response in periodontal disease. In this study, we aimed to analyze the effects of LP533401 in a rat periodontitis model to evaluate the role of gut serotonin in periodontitis pathophysiology. MATERIAL AND

methodsTwenty-four rats were divided into three groups: treated group (T: ligature-induced periodontal disease and LP533401, 25 mg/kg/d) by gavage; ligature group (L: ligature-induced periodontal disease only); and control group (C: without ligature-induced periodontal disease). After 28 d, radiographic alveolar bone support was measured on digital radiographs, and alveolar bone volume fraction, tissue mineral density and trabeculae characteristics were quantified by microcomputed tomography in the right hemi-mandible. Left hemi-mandibles were decalcified and alveolar bone loss, attachment loss and area of collagen in the gingiva were histologically analyzed.

resultsSignificant difference between the L and C groups was found, confirming that periodontal disease was induced. We observed no difference between the T and L groups regarding alveolar bone destruction and area of collagen.

conclusionLP533401 (25 mg/kg/d) for 28 d does not prevent bone loss and does not modulate host response in a rat model of induced periodontal disease.

Indexed as

Alveolar Bone LossAnimalsCollagenDisease Models, AnimalGingivaLigationMaleMandiblePeriodontal Attachment LossPeriodontal DiseasesPeriodontitisPyrimidinesRatsRats, WistarSerotoninX-Ray MicrotomographyCollagenLP533401PyrimidinesSerotoninboneenterochromaffin cellsperiodontitisserotonin

Identifiers

PMID26740292
PMCPMC5630139
OpenAlexW2222533108

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.