ArticleScientific reports2016
Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Adding Tat-Beclin1 to an endurance training program promotes additive improvements in physical function in aged male mice.Physiological reports · 2026Article
- Targeting ORM1-CCR5 axis inhibits the aggressive phenotype of synovial fibroblasts and alleviates RA.Open medicine (Warsaw, Poland) · 2026Article
- ORM2 protects against acute pancreatitis by inhibiting premature activation of pancreatic enzymes.Translational gastroenterology and hepatology · 2026Article
- Resveratrol Alleviated Intensive Exercise-Induced Fatigue Involving in Inhibiting Gut Inflammation and Regulating Gut Microbiota.Food science & nutrition · 2025Article
- Unravelling the transcriptomic symphony of muscle ageing: key pathways and hub genes altered by ageing and caloric restriction in rat muscle revealed by RNA sequencing.BMC genomics · 2025Article
- Article
- Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise.Journal of extracellular vesicles · 2024Article
- Cysteine-cysteine Chemokine Receptor Type 5 Plays a Critical Role in Exercise Performance by Regulating Mitochondrial Content in Skeletal Muscle.Inflammation · 2023Article
- Cystatin-c May Indicate Subclinical Renal Involvement, While Orosomucoid Is Associated with Fatigue in Patients with Long-COVID Syndrome.Journal of personalized medicine · 2023Article
- Sportomics method to assess acute phase proteins in Olympic level athletes using dried blood spots and multiplex assay.Scientific reports · 2022Article
- Orosomucoid: a promising biomarker for the assessment of exercise-induced fatigue triggered by basic combat training.BMC sports science, medicine & rehabilitation · 2022Article
- Mitochondria and Antibiotics: For Good or for Evil?Biomolecules · 2021Review
- Article
- Into the Labyrinth of the Lipocalin α1-Acid Glycoprotein.Frontiers in physiology · 2021Review
- Divergent Regulation of Myotube Formation and Gene Expression by E2 and EPA during In-Vitro Differentiation of C2C12 Myoblasts.International journal of molecular sciences · 2020Article
- Estrogen weakens muscle endurance via estrogen receptor-p38 MAPK-mediated orosomucoid (ORM) suppression.Experimental & molecular medicine · 2018Article
- Article
- Association of serum orosomucoid with 30-min plasma glucose and glucose excursion during oral glucose tolerance tests in non-obese young Japanese women.BMJ open diabetes research & care · 2018Article
- REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise.American journal of physiology. Endocrinology and metabolism · 2017Article
- Muscle fatigue: general understanding and treatment.Experimental & molecular medicine · 2017Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding and managing fatigue is a significant challenge in clinic and society. In attempting to explore how the body responds to and regulates fatigue, we found in rodent fatigue models that orosomucoid 1 (ORM1) was significantly increased in multiple tissues, including blood and muscle. Interestingly, administration of exogenous ORM1 increased muscle glycogen and enhanced muscle endurance, whereas ORM1 deficiency resulted in a significant decrease of muscle endurance both in vivo and in vitro, which could largely be restored by exogenous ORM1. Further studies demonstrated that ORM1 can bind to C-C chemokine receptor type 5 (CCR5) on muscle cells and deletion of the receptor abolished the effect of ORM1. Thus, fatigue upregulates the level of ORM1, which in turn functions as an anti-fatigue protein to enhance muscle endurance via the CCR5 pathway. Modulation of the level of ORM1 and CCR5 signaling could be a novel strategy for the management of fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.