Evidence map›Paper›PMID 26740058›Full record

ArticleMagnetic resonance imaging2016

Performance of simultaneous high temporal resolution quantitative perfusion imaging of bladder tumors and conventional multi-phase urography using a novel free-breathing continuously acquired radial compressed-sensing MRI sequence.

Nainesh Parikh, Justin M Ream, Hoi Cheung Zhang, Kai Tobias Block, Hersh Chandarana, Andrew B Rosenkrantz

Registry-linked trialAbstract read
In one paragraph

Article in Magnetic resonance imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04204876 (Longitudinal Imaging in Patients With Large Vessel Vasculitis to Predict Further Disease Course), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04204876 completednot on this mapstarted 2020, after this paper: background citation

Longitudinal Imaging in Patients With Large Vessel Vasculitis to Predict Further Disease Course

TypeobservationalSponsorUniversity Hospital, Basel, SwitzerlandRan2020 to 2023Enrolled40ConditionsGiant Cell Arteritis, Large Vessel Giant Cell ArteriitisArmsMagnet Resonance Imaging (MRI), PET/CT analysis
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  6. Review
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  9. Review
  10. Compressed sensing for body MRI.Journal of magnetic resonance imaging : JMRI · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nainesh ParikhDepartment of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016. Electronic address: nainesh.parikh@nyumc.org.
Justin M ReamDepartment of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016. Electronic address: Justin.Ream@nyumc.org.
Hoi Cheung ZhangDepartment of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016. Electronic address: HoiCheung.Zhang@nyumc.org.
Kai Tobias BlockDepartment of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016. Electronic address: KaiTobias.Block@nyumc.org.
Hersh ChandaranaDepartment of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016. Electronic address: Hersh.Chandarana@nyumc.org.
Andrew B RosenkrantzDepartment of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016. Electronic address: Andrew.Rosenkrantz@nyumc.org.
NYU Langone Health · US

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Hersh Chandarana · 2014 to 2026
$19.3M
NIBIB NIH HHS P41 EB017183
6 · The paper itself

Abstract

purposeTo investigate the feasibility of high temporal resolution quantitative perfusion imaging of bladder tumors performed simultaneously with conventional multi-phase MR urography (MRU) using a novel free-breathing continuously acquired radial MRI sequence with compressed-sensing reconstruction.

methods22 patients with bladder lesions underwent MRU using GRASP (Golden-angle RAdial Sparse Parallel) acquisition. Multi-phase contrast-enhanced abdominopelvic GRASP was performed during free-breathing (1.4×1.4×3.0mm(3) voxel size; 3:44min acquisition). Two dynamic datasets were retrospectively reconstructed by combining different numbers of sequentially acquired spokes into each dynamic frame: 110 spokes per frame for 25-s temporal resolution (serving as conventional MRU for clinical interpretation) and 8 spokes per frame for 1.7-s resolution. Using 1.7-s resolution images, ROIs were placed within bladder lesions and normal bladder wall, a femoral artery arterial input function was generated, and the Generalized Kinetic Model was applied.

resultsBiopsy/cystectomy demonstrated 16 bladder tumors (13 stage≥T2, 3 stage≤T1) and 6 benign lesions. All lesions were well visualized using 25-s clinical multi-phase images. Using 1.7-s resolution images, K(trans) was significantly higher in tumors (0.38±0.24) than normal bladder (0.12±0.02=8, p<0.001) or benign lesions (0.15±0.04, p=0.033). Ratio between K(trans) of lesions and normal bladder was nearly double for tumors than benign lesions (4.3±3.4 vs. 2.2±1.6), and K(trans) was nearly double in stage≥T2 than stage≤T1 tumors (0.44±0.24 vs. 0.24±0.24), although these did not approach significance (p=0.180-0.209), possibly related to small sample size.

conclusionGRASP allows simultaneous quantitative high temporal resolution perfusion of bladder lesions during clinical MRU examinations using only one contrast injection and without additional scan time.

Indexed as

RespirationAgedContrast MediaFeasibility StudiesFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMalePerfusion ImagingReproducibility of ResultsRetrospective StudiesUrinary BladderUrinary Bladder NeoplasmsUrographyContrast MediaBladder cancerMRI techniquesMR urographyNovel techniques

Identifiers

PMID26740058
PMCPMC4896486
OpenAlexW2232256097

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.