Evidence map›Paper›PMID 26739730›Full record

Trial reportBMJ open2016

Effectiveness of varenicline and counselling for smoking cessation in an observational cohort study in China.

Bin Jiang, Yao He, Fang Zuo, Lei Wu, Qing-Hui Liu, Li Zhang, Chang-Xi Zhou, K K Cheng, Sophia S C Chan, Tai Hing Lam

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01935505 (Study on the Model of Smoking Cessation Intervention and Service Ability Improvement in General Hospital), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01935505 unknown statusnot on this map

Study on the Model of Smoking Cessation Intervention and Service Ability Improvement in General Hospital

TypeobservationalSponsorChinese PLA General HospitalRan2008 to 2018Enrolled2,000ConditionsSmoking CessationArmsConsulting, Nicotine patch, Telephone intervention, Consulting+Telephone+Drug intervention
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Smoking cessation and lung cancer screening.Annals of translational medicine · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bin JiangNanlou Faculty of Clinical Medicine, Department of Traditional Chinese Medicine and Acupuncture, Chinese People's Liberation Army General Hospital, Beijing, China.
Yao HeDepartment of Epidemiology, Institute of Geriatrics, Beijing key laboratory of Aging and Geriatrics, Chinese People's Liberation Army General Hospital, Beijing, China.
Fang ZuoNanlou Faculty of Clinical Medicine, Department of Traditional Chinese Medicine and Acupuncture, Chinese People's Liberation Army General Hospital, Beijing, China.
Lei WuDepartment of Epidemiology, Institute of Geriatrics, Beijing key laboratory of Aging and Geriatrics, Chinese People's Liberation Army General Hospital, Beijing, China.
Qing-Hui LiuNanlou Faculty of Clinical Medicine, Department of Respiration, Chinese People's Liberation Army General Hospital, Beijing, China.
Li ZhangNanlou Faculty of Clinical Medicine, Department of Rehabilitation, Chinese People's Liberation Army General Hospital, Beijing, China.
Chang-Xi ZhouNanlou Faculty of Clinical Medicine, Department of Respiration, Chinese People's Liberation Army General Hospital, Beijing, China.
K K ChengPublic Health, Epidemiology and Biostatistics, University of Birmingham, Birmingham, UK.
Sophia S C ChanSchool of Nursing, School of Public Health, The University of Hong Kong, Hong Kong, China.
Tai Hing LamDepartment of Community Medicine, School of Public Health and The University of Hong Kong, Hong Kong, China.

Funding

Cancer Research UK
6 · The paper itself

Abstract

objectivesTo evaluate the effectiveness of varenicline for smoking cessation in Chinese smokers in a real world cessation clinic practice.

designA prospective observational study.

settingBeijing, China.

participantsA total of 924 smokers (883 men and 41 women) who attended a smoking cessation clinic of a large general hospital were assessed with data from structured questionnaires at baseline and follow-up at 1, 3 and 6 months. Trained physician counsellors provided free individual counselling for all subjects and follow-up interviews with brief counselling. 332 subjects additionally prescribed varenicline according to their own choice were compared with those without varenicline.

main outcome measuresPrimary outcomes were self-reported 7-day point prevalence abstinence rate and 3-month continuous abstinence rate at 6-month follow-up. Secondary outcomes were 7-day point prevalence abstinence rates at 1 and 3-month follow-up, and 1-month continuous abstinence rate at 3-month follow-up.

resultsBy intention-to-treat, the 7-day point prevalence abstinence rate with varenicline and counselling at 6 months was significantly higher than counselling only (37.0% vs 23.1%; OR, 1.75; 95% CI 1.46 to 2.62; p=0.001). The 3-month continuous abstinence rate at 6 months was higher with varenicline (33.1% vs 18.4%; OR, 2.04; 95% CI 1.61 to 2.99; p<0.001). Varenicline also showed better secondary outcomes.

conclusionsVarenicline prescription in the smoking cessation clinic appeared to be effective with doubling of quit rates in Chinese smokers in a real world cessation clinic practice. CLINICAL

trial registrationNCT01935505; Results.

Indexed as

CounselingAdultAmbulatory Care FacilitiesBeijingFemaleHumansMaleMiddle AgedNicotinic AgonistsPhysiciansProspective StudiesSmokingSmoking CessationSurveys and QuestionnairesTobacco Use DisorderTreatment OutcomeNicotinic AgonistsVareniclineEPIDEMIOLOGYPREVENTIVE MEDICINEPUBLIC HEALTH

Identifiers

PMID26739730
PMCPMC4716213

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.