ArticleScientific reports2016
Genome-wide identification of DNA methylation provides insights into the association of gene expression in rice exposed to pesticide atrazine.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 71 citations in OpenAlex.
- Mechanism of atrazine metabolism by the microbial Y9 community and related soil-plant remediation effects.BMC microbiology · 2026Article
- Deciphering Pesticide Stress Responses in Rice Through Integrated Multi-Omic Assessment.Toxics · 2026Review
- Genome-wide DNA methylation dynamics at "heading" stage of panicle and flag leaf in contrasting rice cultivars under field drought conditions.Frontiers in plant science · 2025Article
- Weed biology and management in the multi-omics era: Progress and perspectives.Plant communications · 2024Review
- Symbiotic compatibility between rice cultivars and arbuscular mycorrhizal fungi genotypes affects rice growth and mycorrhiza-induced resistance.Frontiers in plant science · 2023Article
- Editorial: Adaptive evolution of grasses.Frontiers in plant science · 2023Article
- Real-Time Monitoring of the Atrazine Degradation by Liquid Chromatography and High-Resolution Mass Spectrometry: Effect of Fenton Process and Ultrasound Treatment.Molecules (Basel, Switzerland) · 2022Article
- Degradation of Residual Herbicide Atrazine in Agri-Food and Washing Water.Foods (Basel, Switzerland) · 2022Review
- Article
- Herbicide resistance in grass weeds: Epigenetic regulation matters too.Frontiers in plant science · 2022Review
- Residues of Reduced Herbicides Terbuthylazine, Ametryn, and Atrazine and Toxicology to Maize and the Environment through Salicylic Acid.ACS omega · 2021Article
- The Underlying Nature of Epigenetic Variation: Origin, Establishment, and Regulatory Function of Plant Epialleles.International journal of molecular sciences · 2021Review
- Genome Wide MeDIP-Seq Profiling of Wild and Cultivated Olives Trees Suggests DNA Methylation Fingerprint on the Sensory Quality of Olive Oil.Plants (Basel, Switzerland) · 2021Article
- Herbicide stress-induced DNA methylation changes in two Zea mays inbred lines differing in Roundup® resistance.Journal of applied genetics · 2021Article
- Insights into the Role of Transcriptional Gene Silencing in Response to Herbicide-Treatments inInternational journal of molecular sciences · 2021Article
- Integrated analysis of DNA methylome and transcriptome reveals epigenetic regulation of CAM photosynthesis in pineapple.BMC plant biology · 2021Article
- Alterations of Rice (International journal of molecular sciences · 2020Article
- Comparative sequence and methylation analysis of chloroplast and amyloplast genomes from rice.Plant molecular biology · 2019Article
- Article
- Integrative Analysis of Transcriptomic and Methylomic Data in Photoperiod-Dependent Regulation of Cucumber Sex Expression.G3 (Bethesda, Md.) · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atrazine (ATR) is a pesticide widely used for controlling weeds for crop production. Crop contamination with ATR negatively affects crop growth and development. This study presents the first genome-wide single-base-resolution maps of DNA methylation in ATR-exposed rice. Widespread differences were identified in CG and non-CG methylation marks between the ATR-exposed and ATR-free (control) rice. Most of DNA methyltransferases, histone methyltransferases and DNA demethylase were differentially regulated by ATR. We found more genes hypermethylated than those hypomethylated in the regions of upstream, genebody and downstream under ATR exposure. A stringent group of 674 genes (p < 0.05, two-fold change) with a strong preference of differential expression in ATR-exposed rice was identified. Some of the genes were identified in a subset of loss of function mutants defective in DNA methylation/demethylation. Provision of 5-azacytidine (AZA, inhibitor of DNA methylation) promoted the rice growth and reduced ATR content. By UPLC/Q-TOF-MS/MS, 8 degraded products and 9 conjugates of ATR in AZA-treated rice were characterized. Two of them has been newly identified in this study. Our data show that ATR-induced changes in DNA methylation marks are possibly involved in an epigenetic mechanism associated with activation of specific genes responsible for ATR degradation and detoxification.
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