ArticleProceedings of the National Academy of Sciences of the United States of America2016
Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 88 citations in OpenAlex.
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- Functionality of highly diverged Imd like genes identified in stinkbugs and bedbugs.Scientific reports · 2025Article
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- cGLRs Join Their Cousins of Pattern Recognition Receptor Family to Regulate Immune Homeostasis.International journal of molecular sciences · 2024Review
- Drosophila caspases as guardians of host-microbe interactions.Cell death and differentiation · 2023Review
- Integrin-ECM interactions and membrane-associated Catalase cooperate to promote resilience of the Drosophila intestinal epithelium.PLoS biology · 2022Article
- BmNPV p35 Reduces the Accumulation of Virus-Derived siRNAs and Hinders the Function of siRNAs to Facilitate Viral Infection.Frontiers in immunology · 2022Article
- Protein Components of the Arthrodial Membrane Gland in a Neotropical Harvestman (Arachnida, Opiliones).ACS omega · 2021Article
- Transcriptome of the Maize Leafhopper (Microbiology spectrum · 2021Article
- Haemocyte-mediated immunity in insects: Cells, processes and associated components in the fight against pathogens and parasites.Immunology · 2021Review
- Sending Out Alarms: A Perspective on Intercellular Communications in Insect Antiviral Immune Response.Frontiers in immunology · 2021Review
- Unraveling gene content variation across eukaryotic giant viruses based on network analyses and host associations.Virus evolution · 2021Article
- cGAS-STING: insight on the evolution of a primordial antiviral signaling cassette.Faculty reviews · 2021Review
- Locust Hemolymph Conveys Erythropoietin-Like CytoprotectionFrontiers in physiology · 2021Article
- Insights Into the Antiviral Pathways of the SilkwormFrontiers in immunology · 2021Review
- Article
- Mitochondrial and Innate Immunity Transcriptomes from Spodoptera frugiperda Larvae Infected with the Spodoptera frugiperda Ascovirus.Journal of virology · 2020Article
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
Viruses are obligatory intracellular parasites that suffer strong evolutionary pressure from the host immune system. Rapidly evolving viral genomes can adapt to this pressure by acquiring genes that counteract host defense mechanisms. For example, many vertebrate DNA viruses have hijacked cellular genes encoding cytokines or cytokine receptors to disrupt host cell communication. Insect viruses express suppressors of RNA interference or apoptosis, highlighting the importance of these cell intrinsic antiviral mechanisms in invertebrates. Here, we report the identification and characterization of a family of proteins encoded by insect DNA viruses that are homologous to a 12-kDa circulating protein encoded by the virus-induced Drosophila gene diedel (die). We show that die mutant flies have shortened lifespan and succumb more rapidly than controls when infected with Sindbis virus. This reduced viability is associated with deregulated activation of the immune deficiency (IMD) pathway of host defense and can be rescued by mutations in the genes encoding the homolog of IKKγ or IMD itself. Our results reveal an endogenous pathway that is exploited by insect viruses to modulate NF-κB signaling and promote fly survival during the antiviral response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.