Evidence map›Paper›PMID 26739556›Full record

ArticleExperimental dermatology2016

Are itch and scratching the nausea and vomiting of skin?

Sattar Ostadhadi, Ehsan Azimi, Ethan A Lerner, Ahmad-Reza Dehpour

Abstract read
In one paragraph

Article in Experimental dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Physiology and Pathophysiology of Itch.Physiological reviews · 2020
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Sattar OstadhadiExperimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Ehsan AzimiCutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA.
Ethan A LernerCutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA.
Ahmad-Reza DehpourExperimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Funding

Itch, proteases and protease-activated receptorsR01AR057744 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI LERNER, ETHAN A · 2010 to 2014
$1.9M
The role of Mrgprs in substance P-induced itchR21AR067399 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI LERNER, ETHAN A · 2015 to 2016
$489k
NIAMS NIH HHS R01 AR057744NIAMS NIH HHS R21 AR067399
6 · The paper itself

Abstract

The physiologic similarities between itch and nausea may not be evident initially, but they share the role of repelling irritants and toxins from the body by inducting scratching and vomiting, respectively. In addition, itch and nausea frequently occur together in certain conditions such as uraemia. Here we show that the mechanisms underlying itch and nausea overlap and that advances in either field may influence the identification of novel drug targets, particularly for itch.

Indexed as

AnimalsHumansNauseaPruritusitchnauseascratchingvomiting

Identifiers

PMID26739556
PMCPMC5445905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.