ArticleJournal of Zhejiang University. Science. B2016
Changes of testicular phosphorylated proteins in response to restraint stress in male rats.
Article in Journal of Zhejiang University. Science. B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Context-dependent effects of whole-body vibration on reproductive function and penile tissue integrity in sedentary male rats.Experimental physiology · 2026Article
- Preventive Effects of Tri Garn Pis Polyherbal Extract on Sexual Performance, Testicular Apoptosis, and Sperm Quality in a Dexamethasone-Induced Chronic Stress in Mice.Life (Basel, Switzerland) · 2026Article
- Betaine attenuate chronic restraint stress-induced changes in testicular damage and oxidative stress in male mice.Reproductive biology and endocrinology : RB&E · 2022Article
- Effects of treadmill exercise on sexual behavior and reproductive parameters in chronically stressed-male rats.Physiological research · 2021Article
- Chronic stress increases the tyrosine phosphorylation in female reproductive organs: An experimental study.International journal of reproductive biomedicine · 2021Article
- MOTILIPERM Ameliorates Immobilization Stress-Induced Testicular Dysfunction via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway in SD Rats.International journal of molecular sciences · 2020Article
- Protective effect of melatonin against methotrexate-induced testicular damage in the rat model: An experimental study.International journal of reproductive biomedicine · 2020Article
- Expression of testicular phosphorylated proteins in types 1 and 2 diabetes mellitus in mice: An experimental study.International journal of reproductive biomedicine · 2019Article
- Testicular histopathology and phosphorylated protein changes in mice with diabetes induced by multiple-low doses of streptozotocin: An experimental study.International journal of reproductive biomedicine · 2018Article
- Chronic restraint stress induces sperm acrosome reaction and changes in testicular tyrosine phosphorylated proteins in rats.International journal of reproductive biomedicine · 2016Article
- Phyllanthus emblica leaf extract ameliorates testicular damage in rats with chronic stress.Journal of Zhejiang University. Science. BArticle
- Anti-oxidant and anti-apoptotic effects of gamma-oryzanol on male reproductive function in chronic restraint stress in rats.Avicenna journal of phytomedicineArticle
- Distribution and differentiation of myeloid-derived suppressor cells after fluid resuscitation in mice with hemorrhagic shock.Journal of Zhejiang University. Science. BArticle
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate male reproductive parameters via changes of potential testicular protein markers in restraint-stress rats.
methodsMale Sprague-Dawley rats were divided into two groups (non-immobilized control and restraint-immobilized/stress groups, n=8 each group). The stress animals were immobilized (12 h/d) by a restraint cage for 7 consecutive days. All reproductive parameters, morphology and histology were observed and compared between groups. In addition, the expression of steroidogenic acute regulatory (StAR) and phosphotyrosine proteins (previously localized in Sertoli and late spermatid cells) in testicular lysate was assayed by immuno-Western blotting.
resultsTestosterone level, sperm concentration and sperm head normality of stress rats were significantly decreased while the corticosterone level was increased as compared with the control (P<0.05). Histologically, stress rats showed low sperm mass in epididymal lumen and some atrophy of seminiferous tubules. Although the expression of testicular StAR protein was not significantly different between groups, changed patterns of the 131, 95, and 75 kDa testicular phosphorylated proteins were observed in the stress group compared with the control group. The intensity of a testicular 95-kDa phosphorylated protein was significantly decreased in stress rats.
conclusionsThis study has demonstrated the alteration of testicular phosphorylated protein patterns, associated with adverse male reproductive parameters in stress rats. It could be an explanation of some infertility in stress males.
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