ArticleScientific reports2016
MicroRNAs in Honey Bee Caste Determination.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 152 citations in OpenAlex.
- Genome Evolution in Social Insects.Genome biology and evolution · 2026Review
- Comparative Transcriptomic and ceRNA Network Analyses of Non-Coding and Coding RNAs in Heads ofInternational journal of molecular sciences · 2026Article
- A sterility-associated long noncoding RNA involved in honey bee caste determination and adult queen and worker fertility.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Evolution of Bees: Insights from 'Omic Studies.Genome biology and evolution · 2026Review
- Epigenetic Mechanisms inCurrent issues in molecular biology · 2025Review
- Intragenomic conflict associated with extreme phenotypic plasticity in queen-worker caste determination in honey bees (Apis mellifera).Genome biology · 2025Article
- The eusocial non-code: Unveiling the impact of noncoding RNAs on Hymenoptera eusocial evolution.Non-coding RNA research · 2025Review
- Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates?Frontiers in genetics · 2025Article
- De Novo miRNAs fromInsects · 2024Article
- Exploring fatty acids from royal jelly as a source of histone deacetylase inhibitors: from the hive to applications in human well-being and health.Epigenetics · 2024Article
- Article
- Regulation of soldier caste differentiation by microRNAs in Formosan subterranean termite (PeerJ · 2024Article
- Unraveling the modulatory manner and function of circRNAs in the Asian honey bee larval guts.Frontiers in cell and developmental biology · 2024Article
- Diverse Regulatory Manners and Potential Roles of lncRNAs in the Developmental Process of Asian Honey Bee (International journal of molecular sciences · 2023Article
- The genome and sex-dependent responses to temperature in the common yellow butterfly, Eurema hecabe.BMC biology · 2023Article
- Article
- Cross-Kingdom Regulation of Plant-Derived miRNAs in Modulating Insect Development.International journal of molecular sciences · 2023Review
- Phenotypic dimorphism between honeybee queen and worker is regulated by complicated epigenetic modifications.iScience · 2023Article
- Convergent and complementary selection shaped gains and losses of eusociality in sweat bees.Nature ecology & evolution · 2023Article
- Circular RNA ame_circ_2015 Function as microRNA Sponges in Regulating Egg-Laying of Honeybees (Life (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cellular mechanisms employed by some organisms to produce contrasting morphological and reproductive phenotypes from the same genome remains one of the key unresolved issues in biology. Honeybees (Apis mellifera) use differential feeding and a haplodiploid sex determination system to generate three distinct organismal outcomes from the same genome. Here we investigate the honeybee female and male caste-specific microRNA and transcriptomic molecular signatures during a critical time of larval development. Both previously undetected and novel miRNAs have been discovered, expanding the inventory of these genomic regulators in invertebrates. We show significant differences in the microRNA and transcriptional profiles of diploid females relative to haploid drone males as well as between reproductively distinct females (queens and workers). Queens and drones show gene enrichment in physio-metabolic pathways, whereas workers show enrichment in processes associated with neuronal development, cell signalling and caste biased structural differences. Interestingly, predicted miRNA targets are primarily associated with non-physio-metabolic genes, especially neuronal targets, suggesting a mechanistic disjunction from DNA methylation that regulates physio-metabolic processes. Accordingly, miRNA targets are under-represented in methylated genes. Our data show how a common set of genetic elements are differentially harnessed by an organism, which may provide the remarkable level of developmental flexibility required.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.