Evidence map›Paper›PMID 26739408›Full record

ArticleAllergy, asthma & immunology research2016

Defining Chronic Cough: A Systematic Review of the Epidemiological Literature.

Woo Jung Song, Yoon Seok Chang, Shoaib Faruqi, Min Koo Kang, Ju Young Kim, Min Gyu Kang, Sujeong Kim, Eun Jung Jo, Seung Eun Lee, Min Hye Kim and 4 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, asthma & immunology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05042063 (Acoustic Cough Monitoring for the Management of Patients With Known Respiratory Disease), which is not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05042063 completednot on this mapstarted 2021, after this paper: background citation

Acoustic Cough Monitoring for the Management of Patients With Known Respiratory Disease

TypeobservationalSponsorClinica Universidad de Navarra, Universidad de NavarraRan2021 to 2022Enrolled616ConditionsCough, COPD, GERD, AsthmaArmsHyfe Cough Tracker, Hyfe Air
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Woo Jung SongDivision of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Yoon Seok ChangDivision of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Shoaib FaruqiCentre for Cardiovascular and Metabolic Research, Hull York Medical School, Castle Hill Hospital, University of Hull, Cottingham, East Yorkshire, United Kingdom.
Min Koo KangDivision of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Ju Young KimDivision of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Min Gyu KangDepartment of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
Sujeong KimDepartment of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
Eun Jung JoDepartment of Internal Medicine, Pusan National University College of Medicine, Busan, Korea.
Seung Eun LeeDepartment of Internal Medicine, Pusan National University College of Medicine, Busan, Korea.
Min Hye KimDepartment of Internal Medicine, Ewha Woman's University School of Medicine, Seoul, Korea.
Jana PlevkovaDepartment of Pathophysiology and Simulation Centre, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic.
Heung Woo ParkDivision of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Sang Heon ChoDivision of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. shcho@snu.ac.kr.
Alyn H MoriceCentre for Cardiovascular and Metabolic Research, Hull York Medical School, Castle Hill Hospital, University of Hull, Cottingham, East Yorkshire, United Kingdom. a.h.morice@hull.ac.uk.
Seoul National University · KRChungbuk National University · KRHull York Medical School · GBPusan National University · KRComenius University Bratislava · SKEwha Womans University · KRKyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRecent evidence suggests a global burden of chronic cough in general populations. However, the definitions vary greatly among epidemiological studies, and none have been validated for clinical relevance. We aimed to examine previous epidemiological definitions in detail and explore the operational characteristics.

methodsA systematic review was conducted for epidemiological surveys that reported the prevalence of chronic cough in general adult populations during the years 1980 to 2013. A literature search was performed on Pubmed and Embase without language restriction. Epidemiological definitions for chronic cough were classified according to their components, such as cutoff duration. Meta-analyses were performed for the male-to-female ratio of chronic cough prevalence to explore operational characteristics of epidemiological definitions.

resultsA total of 70 studies were included in the systematic review. The most common epidemiological definition was identified as 'cough ≥3 months' duration without specification of phlegm (n=50); however, it conflicted with the cutoff duration in current clinical guidelines (cough ≥8 weeks). Meta-analyses were performed for the male-to-female ratio of chronic cough among 28 studies that reported sex-specific prevalence using the most common definition. The pooled male-to-female odds ratio was 1.26 (95% confidence interval 0.92-1.73) with significant heterogeneity (I²=96%, P<0.001), which was in contrast to clinical observations of female predominance from specialist clinics. Subgroup analyses did not reverse the ratio or reduce the heterogeneity.

conclusionsThis study identified major issues in defining chronic cough in future epidemiological studies. The conflict between epidemiological and clinical diagnostic criteria needs to be resolved. The unexpected difference in the gender predominance between the community and clinics warrants further studies. Clinical validation of the existing definition is required.

Indexed as

Coughdefinitionepidemiology

Identifiers

PMID26739408
PMCPMC4713878
OpenAlexW1940329381

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.