ArticlePlant physiology2016
Comprehensive Profiling of Ethylene Response Factor Expression Identifies Ripening-Associated ERF Genes and Their Link to Key Regulators of Fruit Ripening in Tomato.
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Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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98citing papers in PubMed
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98 citing papers in PubMed, 217 citations in OpenAlex.
- The regulatory role of DzERF94 in carotenoid biosynthesis during ripening in durian (Durio zibethinus) pulp.Plant cell reports · 2026Article
- Haplotype-resolved regulation of secondary metabolism in cannabis.Horticulture research · 2026Article
- Functional study of the AfRAP2 gene in Amorpha fruticosa L. tolerance to saline-alkali and drought stress.BMC plant biology · 2026Article
- CpERF-WRI1 Manipulates Ethylene Sensing by Regulating the Expression of CpERS1 and Fruit Ripening in Papaya.Plant biotechnology journal · 2026Article
- The carotenoids metabolism during tomato fruit ripening: insights into multi-level regulatory network.BMC plant biology · 2026Review
- Rewiring of auxin and MAPK signaling is associated with contrasting shoestring and fern-like manifestations in ToBRFV-A134T-infected tomato.Frontiers in plant science · 2026Article
- Generating drought- and salt-tolerant tomato germplasm through bioengineering of the ethylene response factor SlERF.J2.Engineering in life sciences · 2026Article
- SlERF.D2-mediated antagonism between ethylene and ABA signaling pathways modulates osmotic stress adaptation in tomato.Horticulture research · 2026Article
- Silencing of SlERF.F5 affects tolerance to drought, salt and low-temperature stresses in tomato.BMC genomics · 2025Article
- Transcriptional control of tomato fruit development and ripening.Journal of experimental botany · 2025Review
- Organ-level gene-regulatory networks inferred from transcriptomic data reveal context-specific regulation and highlight novel regulators of ripening and ABA-mediated responses in tomato.Plant communications · 2025Article
- The ethylene response factor ERF1A regulates UV-C-induced delayed ripening in peach fruit.Plant physiology · 2025Article
- Integration of GWAS and transcriptome approaches for the identification of nitrogen-, phosphorus-, and potassium-responsive genes in tomato.Horticulture research · 2025Article
- DNA Methylation Profile Changes in CpG Islands of Ethylene-Signaling Genes Regulated by Melatonin Were Involved in Alleviating Chilling Injury of Postharvest Tomato Fruit.International journal of molecular sciences · 2025Article
- Functional redundancy of transcription factors SlNOR and SlNOR-like1 is required for pollen development in tomato.Horticulture research · 2025Article
- Modulation of Root Hydrotropism and Recovery From Drought by MIZ1-like Genes in Tomato.Plant, cell & environment · 2025Article
- Ethylene response factor SlERF.D6 promotes ripening in part through transcription factors SlDEAR2 and SlTCP12.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Determining the function of ripening associated genes and biochemical changes during tomato (Solanum lycopersicum L.) fruit maturation.Biotechnology letters · 2025Article
- Genome-wide analysis of AP2/ERF transcription Factors inFrontiers in plant science · 2025Article
- DNA Methylation Is Crucial for 1-Methylcyclopropene Delaying Postharvest Ripening and Senescence of Tomato Fruit.International journal of molecular sciences · 2024Article
38 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 3 countries.
Mingchun LiuKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610014, China (M.L.);Université de Toulouse, Institut National Polytechnique de Toulouse-Ecole Nationale Supérieure Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Institut National de la Recherche Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Department of Food and Experimental Nutrition, NAPAN/FoRC Food Research Center, Universidade de São Paulo, School of Pharmaceutical Sciences, 05508-000 Sao Paulo, Sao Paulo, Brazil (B.L.G., E.P.); andDepartamento de Ciências Biológicas, Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, 13418-900 Piracicaba, Sao Paulo, Brazil (L.E.P.P.) liumingchun1982102@163.com julien.pirrello@ensat.fr.ORCID http://orcid.org/0000-0001-8004-1758
Bruna Lima GomesKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610014, China (M.L.);Université de Toulouse, Institut National Polytechnique de Toulouse-Ecole Nationale Supérieure Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Institut National de la Recherche Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Department of Food and Experimental Nutrition, NAPAN/FoRC Food Research Center, Universidade de São Paulo, School of Pharmaceutical Sciences, 05508-000 Sao Paulo, Sao Paulo, Brazil (B.L.G., E.P.); andDepartamento de Ciências Biológicas, Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, 13418-900 Piracicaba, Sao Paulo, Brazil (L.E.P.P.).
Isabelle MilaKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610014, China (M.L.);Université de Toulouse, Institut National Polytechnique de Toulouse-Ecole Nationale Supérieure Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Institut National de la Recherche Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Department of Food and Experimental Nutrition, NAPAN/FoRC Food Research Center, Universidade de São Paulo, School of Pharmaceutical Sciences, 05508-000 Sao Paulo, Sao Paulo, Brazil (B.L.G., E.P.); andDepartamento de Ciências Biológicas, Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, 13418-900 Piracicaba, Sao Paulo, Brazil (L.E.P.P.).
Eduardo PurgattoKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610014, China (M.L.);Université de Toulouse, Institut National Polytechnique de Toulouse-Ecole Nationale Supérieure Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Institut National de la Recherche Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Department of Food and Experimental Nutrition, NAPAN/FoRC Food Research Center, Universidade de São Paulo, School of Pharmaceutical Sciences, 05508-000 Sao Paulo, Sao Paulo, Brazil (B.L.G., E.P.); andDepartamento de Ciências Biológicas, Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, 13418-900 Piracicaba, Sao Paulo, Brazil (L.E.P.P.).ORCID http://orcid.org/0000-0002-7372-1197
Lázaro E P PeresKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610014, China (M.L.);Université de Toulouse, Institut National Polytechnique de Toulouse-Ecole Nationale Supérieure Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Institut National de la Recherche Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Department of Food and Experimental Nutrition, NAPAN/FoRC Food Research Center, Universidade de São Paulo, School of Pharmaceutical Sciences, 05508-000 Sao Paulo, Sao Paulo, Brazil (B.L.G., E.P.); andDepartamento de Ciências Biológicas, Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, 13418-900 Piracicaba, Sao Paulo, Brazil (L.E.P.P.).ORCID http://orcid.org/0000-0002-8761-5934
Pierre FrasseKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610014, China (M.L.);Université de Toulouse, Institut National Polytechnique de Toulouse-Ecole Nationale Supérieure Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Institut National de la Recherche Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Department of Food and Experimental Nutrition, NAPAN/FoRC Food Research Center, Universidade de São Paulo, School of Pharmaceutical Sciences, 05508-000 Sao Paulo, Sao Paulo, Brazil (B.L.G., E.P.); andDepartamento de Ciências Biológicas, Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, 13418-900 Piracicaba, Sao Paulo, Brazil (L.E.P.P.).
Elie MazaKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610014, China (M.L.);Université de Toulouse, Institut National Polytechnique de Toulouse-Ecole Nationale Supérieure Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Institut National de la Recherche Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Department of Food and Experimental Nutrition, NAPAN/FoRC Food Research Center, Universidade de São Paulo, School of Pharmaceutical Sciences, 05508-000 Sao Paulo, Sao Paulo, Brazil (B.L.G., E.P.); andDepartamento de Ciências Biológicas, Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, 13418-900 Piracicaba, Sao Paulo, Brazil (L.E.P.P.).ORCID http://orcid.org/0000-0002-7351-6345
Mohamed ZouineKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610014, China (M.L.);Université de Toulouse, Institut National Polytechnique de Toulouse-Ecole Nationale Supérieure Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Institut National de la Recherche Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Department of Food and Experimental Nutrition, NAPAN/FoRC Food Research Center, Universidade de São Paulo, School of Pharmaceutical Sciences, 05508-000 Sao Paulo, Sao Paulo, Brazil (B.L.G., E.P.); andDepartamento de Ciências Biológicas, Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, 13418-900 Piracicaba, Sao Paulo, Brazil (L.E.P.P.).
Jean-Paul RoustanKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610014, China (M.L.);Université de Toulouse, Institut National Polytechnique de Toulouse-Ecole Nationale Supérieure Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Institut National de la Recherche Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Department of Food and Experimental Nutrition, NAPAN/FoRC Food Research Center, Universidade de São Paulo, School of Pharmaceutical Sciences, 05508-000 Sao Paulo, Sao Paulo, Brazil (B.L.G., E.P.); andDepartamento de Ciências Biológicas, Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, 13418-900 Piracicaba, Sao Paulo, Brazil (L.E.P.P.).ORCID http://orcid.org/0000-0001-7707-7776
Mondher BouzayenKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610014, China (M.L.);Université de Toulouse, Institut National Polytechnique de Toulouse-Ecole Nationale Supérieure Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Institut National de la Recherche Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Department of Food and Experimental Nutrition, NAPAN/FoRC Food Research Center, Universidade de São Paulo, School of Pharmaceutical Sciences, 05508-000 Sao Paulo, Sao Paulo, Brazil (B.L.G., E.P.); andDepartamento de Ciências Biológicas, Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, 13418-900 Piracicaba, Sao Paulo, Brazil (L.E.P.P.).
Julien PirrelloKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610014, China (M.L.);Université de Toulouse, Institut National Polytechnique de Toulouse-Ecole Nationale Supérieure Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Institut National de la Recherche Agronomique, Unité Mixte de Recherche 990 Génomique et Biotechnologie des Fruits, Castanet-Tolosan, F-31326, France (M.L., B.L.G., I.M., P.F., E.M., M.Z., J.-P.R., M.B., J.P.);Department of Food and Experimental Nutrition, NAPAN/FoRC Food Research Center, Universidade de São Paulo, School of Pharmaceutical Sciences, 05508-000 Sao Paulo, Sao Paulo, Brazil (B.L.G., E.P.); andDepartamento de Ciências Biológicas, Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, 13418-900 Piracicaba, Sao Paulo, Brazil (L.E.P.P.) liumingchun1982102@163.com julien.pirrello@ensat.fr.ORCID http://orcid.org/0000-0002-5725-885X
Université Fédérale de Toulouse Midi-Pyrénées · FRUniversidade de São Paulo · BRSichuan University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our knowledge of the factors mediating ethylene-dependent ripening of climacteric fruit remains limited. The transcription of ethylene-regulated genes is mediated by ethylene response factors (ERFs), but mutants providing information on the specific role of the ERFs in fruit ripening are still lacking, likely due to functional redundancy among this large multigene family of transcription factors. We present here a comprehensive expression profiling of tomato (Solanum lycopersicum) ERFs in wild-type and tomato ripening-impaired tomato mutants (Never-ripe [Nr], ripening-inhibitor [rin], and non-ripening [nor]), indicating that out of the 77 ERFs present in the tomato genome, 27 show enhanced expression at the onset of ripening while 28 display a ripening-associated decrease in expression, suggesting that different ERFs may have contrasting roles in fruit ripening. Among the 19 ERFs exhibiting the most consistent up-regulation during ripening, the expression of 11 ERFs is strongly down-regulated in rin, nor, and Nr tomato ripening mutants, while only three are consistently up-regulated. Members of subclass E, SlERF.E1, SlERF.E2, and SlERF.E4, show dramatic down-regulation in the ripening mutants, suggesting that their expression might be instrumental in fruit ripening. This study illustrates the high complexity of the regulatory network connecting RIN and ERFs and identifies subclass E members as the most active ERFs in ethylene- and RIN/NOR-dependent ripening.
Indexed as
Cluster AnalysisEthylenesFruitGene Expression ProfilingGene Expression Regulation, PlantGene Regulatory NetworksGenes, PlantGenes, RegulatorMutationPlant Growth RegulatorsPlant ProteinsPromoter Regions, GeneticResponse ElementsReverse Transcriptase Polymerase Chain ReactionSolanum lycopersicumethyleneEthylenesPlant Growth RegulatorsPlant Proteins
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