Evidence map›Paper›PMID 26739062›Full record

ReviewCancer letters2016

Commensal bacteria modulate the tumor microenvironment.

Theofilos Poutahidis, Susan E Erdman

Abstract readReview
In one paragraph

Review in Cancer letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  6. Article
  7. Article
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  10. Review
  11. Article
  12. Bacterial infection and microbiota in carcinogenesis and tumor development.Frontiers in cellular and infection microbiology · 2023
    Review
  13. Review
  14. Article
  15. Gut Microbiota and Immunotherapy.Frontiers in microbiology · 2022
    Review
  16. Review
  17. Article
  18. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Theofilos PoutahidisDivision of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Greece 54124.
Susan E ErdmanDivision of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: serdman@mit.edu.

Funding

GI Tract Dysbiosis and Breast CancerU01CA164337 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ERDMAN, SUSAN E, WANG, TIMOTHY CRAGIN · 2012 to 2016
$2.6M
Role of IL10 and TGFb1 in colon cancerR01CA108854 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ERDMAN, SUSAN E · 2005 to 2014
$2.4M
NCI NIH HHS R01 CA108854NCI NIH HHS U01 CA164337
6 · The paper itself

Abstract

It has been recently shown that gut microbes modulate whole host immune and hormonal factors impacting the fate of distant preneoplastic lesions toward malignancy or regression. This raises the possibility that the tumor microenvironment interacts with broader systemic microbial-immune networks. These accumulated findings suggest novel therapeutic opportunities for holobiont engineering in emerging tumor microenvironments.

Indexed as

Cell Transformation, NeoplasticGastrointestinal MicrobiomeTumor MicroenvironmentAnimalsBacteriaHost-Pathogen InteractionsHumansNeoplasmsRisk FactorsSignal TransductionSymbiosisCarcinogenesisCommensalMicrobesTumor macroenvironmentTumor microenvironment

Identifiers

PMID26739062
PMCPMC4942371

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.