Observational studyPediatrics2016
Parental Depression and Pancreatic Enzymes Adherence in Children With Cystic Fibrosis.
Observational study in Pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Parent Coping Support Interventions During Acute Pediatric Hospitalizations: A Meta-Analysis.Pediatrics · 2017Pooled it
- Caregiver burden in cystic fibrosis: a systematic literature review.Therapeutic advances in respiratory diseasePooled it
- Trial
- Perinatal Depression and Infant Mortality.JAMA network open · 2026Article
- Parental depressive symptoms link family income to preschool child mental health in Western China.Frontiers in public health · 2026Article
- Anxiety, depression and fear of disease progression among Chinese parents of children with retinoblastoma.BMC psychiatry · 2025Article
- Challenges to Optimizing Nutrition in Children With Cystic Fibrosis.Current gastroenterology reports · 2025Review
- Psychosocial and mental health in cystic fibrosis in the modern era of care: time to evolve.BMJ open respiratory research · 2025Review
- Depression and anxiety in adolescents with cystic fibrosis in Brazil: prevalence, stability over time, and relationship with treatment adherence.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Observational
- Treatment of Psychological Symptoms in Patients with Cystic Fibrosis.Journal of clinical medicine · 2024Review
- Article
- Impact of COVID-19 on mental health: Effects on screening, care delivery, and people with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2021Article
- Anxiety and depression in Dutch patients with primary ciliary dyskinesia and their caregivers: associations with health-related quality of life.ERJ open research · 2021Article
- Systematic depression and anxiety screening for patients and caregivers: implementation and process improvement in a cystic fibrosis clinic.BMJ open quality · 2021Article
- Influence of Cystic Fibrosis-Related Diabetes on Mental Health in Adults: A Single-Center Study.Lung · 2020Article
- Effect of the COVID-19 pandemic on anxiety among children with cystic fibrosis and their mothers.Pediatric pulmonology · 2020Article
- To attend, or not to attend: Examining caregiver intentions and study compliance in a pediatric, randomized controlled trial.Clinical trials (London, England) · 2020Article
- A multiple methods approach to determine adherence with prescribed mycophenolate in children with kidney transplant.British journal of clinical pharmacology · 2019Article
- Adherence to long-term therapies in cystic fibrosis: a French cross-sectional study linking prescribing, dispensing, and hospitalization data.Patient preference and adherence · 2019Article
- Depression Among Caregivers of Children with Cystic Fibrosis: Causes and Solutions.Indian journal of pediatrics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
backgroundTreatment adherence in cystic fibrosis (CF) is often poor, however, less is known about adherence to pancreatic enzymes, a critical component of the CF treatment regimen. Parent caregivers often report elevations in depression, and parental depression may adversely affect children's adherence.
methodsThis prospective study evaluated adherence to pancreatic enzymes in 83 patients (1-13 years) . Adherence was measured across 3 months with electronic pill-caps . Weight was measured at baseline and a 3-month follow-up. Parental depressive symptoms were evaluated by using the Center for Epidemiologic Studies Depression Scale (CES-D).
resultsAdherence to pancreatic enzymes was 49.4% ± 3.4%. Adherence was higher at school (94.4% ± 6.1%) than at home (42.3% ± 3.1%), and higher for toddlers (50.6% ± 5.2%) than for school-aged children (37.5% ± 3.7%). Parents reported high rates of depressive symptoms (30% in the clinical range, 18% with moderate symptoms). Children of parents with symptoms of depression versus those without were less adherent (34.8% ± 4.5% vs 48.5% ± 4.1%), and adherence to enzymes was significantly related to 3-month weight outcomes. Average gain in weight z scores across 3 months was 0.5 ± 0.2for children who were >50% adherent and -0.1 ± 6.1for children who were <33% adherent. Parental depression had a signifcant, indirect effect on weight via adherence (-0.005 ± 0.003 gain in weight z score per CES-D unit ).
conclusionsHigh rates of parental depressive symptoms, coupled with its negative effects on adherence, suggest that measuring and treating parental depression may improve children's adherence to therapy.
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