Evidence map›Paper›PMID 26738772›Full record

ReviewExperimental dermatology2016

Antimicrobial peptides and wound healing: biological and therapeutic considerations.

Maria Luisa Mangoni, Alison M McDermott, Michael Zasloff

Abstract readReview
In one paragraph

Review in Experimental dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Toxins turned into medicines: A systematic review of peptide animal-derived venom in wound treatments.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026
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127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Maria Luisa MangoniDepartment of Biochemical Sciences 'A. Rossi Fanelli', Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.
Alison M McDermottThe Ocular Surface Institute, College of Optometry, University of Houston, Houston, TX, USA.
Michael ZasloffMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA.

Funding

Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI LAURA J. FRISHMAN · 1988 to 2026
$16.4M
Role of Antimicrobial Peptides at the Ocular SurfaceR01EY013175 · NEI · UNIVERSITY OF HOUSTON · PI MCDERMOTT, ALISON M · 2001 to 2016
$4.3M
NEI NIH HHS EY13175NEI NIH HHS P30 EY007551NEI NIH HHS R01 EY013175
6 · The paper itself

Abstract

Repair of tissue wounds is a fundamental process to re-establish tissue integrity and regular function. Importantly, infection is a major factor that hinders wound healing. Multicellular organisms have evolved an arsenal of host-defense molecules, including antimicrobial peptides (AMPs), aimed at controlling microbial proliferation and at modulating the host's immune response to a variety of biological or physical insults. In this brief review, we provide the evidence for a role of AMPs as endogenous mediators of wound healing and their promising therapeutic potential for the treatment of non-life-threatening skin and other epithelial injuries.

Indexed as

AnimalsAnti-Infective AgentsAntimicrobial Cationic PeptidesBacterial InfectionsCaenorhabditis elegansCathelicidinsDrosophila melanogasterEpithelial CellsHumansImmune SystemImmunity, InnateMiceMicrobiotaSkinWound HealingAnti-Infective AgentsAntimicrobial Cationic PeptidesCathelicidinsantibiotic resistanceantimicrobial peptidefrog skininnate immunityskin infectionswound healing

Identifiers

PMID26738772
PMCPMC4789108

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.