ArticleBMC genetics2016
Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe.
Article in BMC genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 63 citations in OpenAlex.
- Bridging life satisfaction data and neurobiological measures would elucidate human well-being.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes.Nature genetics · 2025Article
- Article
- Maternal outcomes related to Genetic and epigenetic Variation in the oxytocin system: A scoping review.Comprehensive psychoneuroendocrinology · 2023Article
- Oxytocin receptor single nucleotide polymorphism predicts atony-related postpartum hemorrhage.BMC pregnancy and childbirth · 2022Article
- The Interaction Effect of Parental Rejection and Oxytocin Receptor Gene Polymorphism on Depression: A Cross-Cultural Study in Non-Clinical Samples.International journal of environmental research and public health · 2022Article
- Gene-Environment Interactions in Face Categorization: Oxytocin Receptor Genotype x Childcare Experience Shortens Reaction Time.Frontiers in psychology · 2022Article
- An interaction between early threat exposure and the oxytocin receptor in females: Disorder-specific versus general risk for psychopathology and social-emotional mediators.Development and psychopathology · 2021Article
- Impact ofFrontiers in genetics · 2021Article
- Strategies for Sharing Limited Resources among Children and Adolescents in Three Traditional Societies of East Africa: Sociocultural and Genetic Factors.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2020Article
- Oxytocin receptor gene polymorphism (rs53576) and digit ratio associates with aggression: comparison in seven ethnic groups.Journal of physiological anthropology · 2020Article
- Examining the link between emotional childhood abuse and social relationships in midlife: The moderating role of the oxytocin receptor gene.Child abuse & neglect · 2019Article
- A biocultural approach to psychiatric illnesses.Psychopharmacology · 2019Review
- Associations between the oxytocin receptor gene (OXTR) rs53576 polymorphism and emotional processing of social and nonsocial cues: an event-related potential (ERP) study.Journal of physiological anthropology · 2017Article
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Authors and funding
10 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe oxytocin (OT) system is known to be implicated in the regulation of complex social behavior, particularly empathy and parenting. The goal of this study was to estimate the gender and population differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in four populations.
resultsThese data were compared with each other and with 14 samples from the corresponding regions retrieved from the 1000 Genomes database. Low level of heterozygosity was observed for both SNPs in all populations in this study (rs53576: Catalonian, Hobs = 0.413; Hadza, Hobs = 0.556; sr2254698: Khanty-Mansi, Hobs = 0.250; Datoga, Hobs = 0.550). The amount of variance due to regional variability was almost equal for both SNPs (rs53576: FRT = 0.086, rs2554298: FRT = 0.072), whereas variance for the population level of variability was twice bigger for rs2554298 (rs53576: FST = 0.127, rs2554298: FST = 0.162). Pairwise coefficients of fixation demonstrate that the Hadza were well differentiated from other African populations except of Datoga, the Datoga were weakly differentiated from other African origin populations, the Ob Ugric people were extremely differentiated from all other populations. Catalans were extremely differentiated of Asian populations.
conclusionsIt is hypothesized on the base of spatial distribution of the evolutionary novel A alleles of the both OXTR gene loci, that the spread of alleles of rs22542298 and rs53376 SNPs may be associated to some extant with manipulation of parental investment in humans.
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