ArticleSchizophrenia bulletin2016
Schizophrenia Spectrum Disorders in a Danish 22q11.2 Deletion Syndrome Cohort Compared to the Total Danish Population--A Nationwide Register Study.
Article in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Opposing white matter microstructure abnormalities in 22q11.2 deletion and duplication carriers.Translational psychiatry · 2021Article
- Association of a functional Claudin-5 variant with schizophrenia in female patients with the 22q11.2 deletion syndrome.Schizophrenia research · 2020Article
- Prevalence of rearrangements in the 22q11.2 region and population-based risk of neuropsychiatric and developmental disorders in a Danish population: a case-cohort study.The lancet. Psychiatry · 2018Article
- 22q11.2 Deletion Syndrome Is Associated With Impaired Auditory Steady-State Gamma Response.Schizophrenia bulletin · 2018Article
- Differential DNA methylation at birth associated with mental disorder in individuals with 22q11.2 deletion syndrome.Translational psychiatry · 2017Article
- Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome.Journal of neurodevelopmental disorders · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCross-sectional studies have shown associations between 22q11.2 deletion syndrome and schizophrenia. However, large-scale prospective studies have been lacking. We, therefore, conducted the first large-scale population based study on the risk of being diagnosed with schizophrenia in persons identified with 22q11.2 deletion syndrome.
methodsDanish nationwide registers were linked to establish a cohort consisting of all Danish citizens born during 1955-2004 and the cohort was followed from January 1, 1994 until December 31, 2013. Data were analyzed using survival analyses and adjusted for calendar year, age, sex, and parental mental health history.
resultsA total of 156 individuals with 22q11.2 deletion syndrome were identified, out of which 6 individuals were diagnosed with schizophrenia spectrum disorders following identification with 22q11 deletion syndrome. Identified carriers of 22q11.2 deletion had an 8.13(95% CI: 3.65-18.09) fold increased risk of schizophrenia spectrum disorder.
conclusionsCarriers of a 22q11.2 deletion who had been clinically identified had a highly increased risk of schizophrenia spectrum disorders.
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