SynthesisSchizophrenia bulletin2016
Working Memory in Unaffected Relatives of Patients With Schizophrenia: A Meta-Analysis of Functional Magnetic Resonance Imaging Studies.
Synthesis in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Altered amygdala resting-state functional connectivity in anxiety disorders: a coordinate-based meta-analysis.Psychological medicine · 2026Pooled it
- Cognitive Brain Signatures of Youth With Early Onset and Relatives With Schizophrenia: Evidence From fMRI Meta-analyses.Schizophrenia bulletin · 2020Pooled it
- Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Independence-based causal discovery analysis reveals statistically non-significant regions to be functionally significant.bioRxiv : the preprint server for biology · 2025Article
- Resting-state degree centrality and Granger causality analysis in relation to facial working memory in patients with first-episode schizophrenia.BMC psychiatry · 2025Article
- Enhancing task fMRI individual difference research with neural signatures.medRxiv : the preprint server for health sciences · 2025Article
- Abnormal trial-to-trial variability in P300 time-varying directed eeg network of schizophrenia.Medical & biological engineering & computing · 2024Article
- The Risk for Schizophrenia-Bipolar Spectrum: Does the Apple Fall Close to the Tree? A Narrative Review.International journal of environmental research and public health · 2023Review
- Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function.BMC medicine · 2023Article
- A significant, functional and replicable risk KTN1 variant block for schizophrenia.Scientific reports · 2023Article
- Cognitive [Computational] Neuroscience Test Reliability and Clinical Applications for Serious Mental Illness (CNTRaCS) Consortium: Progress and Future Directions.Current topics in behavioral neurosciences · 2023Article
- Article
- A Possible White Matter Compensating Mechanism in the Brain of Relatives of People Affected by Psychosis Inferred from Repeated Long-Term DTI Scans.Schizophrenia bulletin open · 2022Article
- Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- The VNTR of thePsychological medicine · 2021Article
- A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MTd2d3 and Mushroom Dendritic Spine Density.Schizophrenia bulletin · 2021Article
- Altered thalamocortical structural connectivity in persons with schizophrenia and healthy siblings.NeuroImage. Clinical · 2020Article
- Functional Connectivity Combined With a Machine Learning Algorithm Can Classify High-Risk First-Degree Relatives of Patients With Schizophrenia and Identify Correlates of Cognitive Impairments.Frontiers in neuroscience · 2020Article
- Polygenic risk score increases schizophrenia liability through cognition-relevant pathways.Brain : a journal of neurology · 2019Article
- Abnormal neural hierarchy in processing of verbal information in patients with schizophrenia.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Working memory deficits, a core cognitive feature of schizophrenia may arise from dysfunction in the frontal and parietal cortices. Numerous studies have also found abnormal neural activation during working memory tasks in patients' unaffected relatives. The aim of this study was to systematically identify and anatomically localize the evidence for those activation differences across all eligible studies. Fifteen functional magnetic resonance imaging (fMRI) manuscripts, containing 16 samples of 289 unaffected relatives of patients with schizophrenia, and 358 healthy controls were identified that met our inclusion criteria: (1) used a working memory task; and (2) reported standard space coordinates. Activation likelihood estimation (ALE) identified convergence across studies. Compared to healthy controls, patients' unaffected relatives showed decreases in neural activation in the right middle frontal gyrus (BA9), as well as right inferior frontal gyrus (BA44). Increased activation was seen in relatives in the right frontopolar (BA10), left inferior parietal lobe (BA40), and thalamus bilaterally. These results suggest that the familial risk of schizophrenia is expressed in changes in neural activation in the unaffected relatives in the cortical-subcortical working memory network that includes, but is not restricted to the middle prefrontal cortex.
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