Evidence map›Paper›PMID 26738424›Full record

ArticleScientific reports2016

Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription.

Hui Han, Jialin Fan, Yue Xiong, Wenqing Wu, Yi Lu, Lei Zhang, Yun Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hui HanState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai, Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Jialin FanState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai, Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Yue XiongState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai, Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Wenqing WuState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai, Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Yi LuState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai, Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Lei ZhangState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai, Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Yun ZhaoState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai, Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene apterous (ap), chip (chi) and beadex (bx) play important roles in the dorsal-ventral compartmentalization in Drosophila wing discs. Meanwhile, Notch signaling is essential to the same process. It has been reported that Ap and Chi function as a tetramer to regulate Notch signaling. At the same time, dLMO (the protein product of gene bx) regulates the activity of Ap by competing its binding with Chi. However, the detailed functions of Chi and dLMO on Notch signaling and the relevant mechanisms remain largely unknown. Here, we report the detailed functions of Chi and dLMO on Notch signaling. Different Chi protein levels in adjacent cells could activate Notch signaling mainly in the cells with higher level of Chi. dLMO could induce antagonistical phenotypes on Notch signaling compared to that induced by Chi. These processes depend on their direct regulation of fringe (fng) transcription.

Indexed as

AnimalsCell LineDrosophila melanogasterDrosophila ProteinsHomeodomain ProteinsN-AcetylglucosaminyltransferasesNuclear ProteinsProtein MultimerizationReceptors, NotchSignal TransductionTranscriptional ActivationTranscription, GeneticBx protein, DrosophilaChi protein, DrosophilaDrosophila Proteinsfng protein, DrosophilaHomeodomain ProteinsN-AcetylglucosaminyltransferasesN protein, DrosophilaNuclear ProteinsReceptors, Notch

Identifiers

PMID26738424
PMCPMC4704065

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.