ArticleBiomacromolecules2016
Thermoresponsive and Mechanical Properties of Poly(L-proline) Gels.
Article in Biomacromolecules, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Gelation behavior of short protected peptides in organic medium.Soft matter · 2025Article
- Digital Light Processing of Thermoresponsive Hydrogels from Polyproline-Based Star Polypeptides.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Exosomes derived from epidermal growth factor-like domain protein 6-preconditioned mesenchymal stem cells for diabetic wound healing.Regenerative therapy · 2024Article
- Clickable Polyprolines from Azido-prolineACS polymers Au · 2023Article
- High Molecular Weight Polyproline as a Potential Biosourced Ice Growth Inhibitor: Synthesis, Ice Recrystallization Inhibition, and Specific Ice Face Binding.Biomacromolecules · 2023Article
- Memory Effect in Thermoresponsive Proline-based Polymers.Angewandte Chemie (International ed. in English) · 2022Article
- Water-assisted and protein-initiated fast and controlled ring-opening polymerization of prolineNational science review · 2022Article
- Reduced Graphene Oxide Incorporated GelMA Hydrogel Promotes Angiogenesis For Wound Healing Applications.International journal of nanomedicine · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Gelation of the left helical N-substituted homopolypeptide poly(L-proline) (PLP) in water was explored, employing rheological and small-angle scattering studies at different temperatures and concentrations in order to investigate the network structure and its mechanical properties. Stiff gels were obtained at 10 wt % or higher at 5 °C, the first time gelation has been observed for homopolypeptides. The secondary structure and helical rigidity of PLP has large structural similarities to gelatin but as gels the two materials show contrasting trends with temperature. With increasing temperature in D2O, the network stiffens, with broad scattering features of similar correlation length for all concentrations and molar masses of PLP. A thermoresponsive transition was also achieved between 5 and 35 °C, with moduli at 35 °C higher than gelatin at 5 °C. The brittle gels could tolerate strains of 1% before yielding with a frequency-independent modulus over the observed range, similar to natural proline-rich proteins, suggesting the potential for thermoresponsive or biomaterial-based applications.
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Registered trials
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