ArticleThe Clinical journal of pain2016
Acute Low Back Pain: Differential Somatosensory Function and Gene Expression Compared With Healthy No-Pain Controls.
Article in The Clinical journal of pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01981382 (Characterizing Pain Sensitivity in Persistent Nonspecific Low Back Pain), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterizing Pain Sensitivity in Persistent Nonspecific Low Back Pain
Who cites it
29 citing papers in PubMed, 52 citations in OpenAlex.
- Elevated Production of Nociceptive CC Chemokines and sE-Selectin in Patients With Low Back Pain and the Effects of Spinal Manipulation: A Nonrandomized Clinical Trial.The Clinical journal of pain · 2018Trial
- Immune system expression profiling in patients experiencing low back pain: A pilot study.PM & R : the journal of injury, function, and rehabilitation · 2026Observational
- Sensory Organization and Postural Control Strategies During Quiet Standing in People with Acute Low Back Pain: A Case-Control Study.The archives of bone and joint surgery · 2026Article
- Differential Gene Expression in Pain-Related Genes are not Affected by the Presence of Dementia.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2024Article
- Testing Biological and Psychological Pathways of Emotion Regulation as a Primary Mechanism of Action in Yoga Interventions for Chronic Low Back Pain: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2024Article
- Protocol for Biospecimen Collection and Analysis Within the BACPAC Research Program.Pain medicine (Malden, Mass.) · 2023Article
- Associations between psychological factors, pressure pain thresholds and conditioned pain modulation and disability in (sub)-acute low back pain: a three-month follow-up study.The Journal of manual & manipulative therapy · 2023Article
- Pressure Pain Thresholds and Central Sensitization in Relation to Psychosocial Predictors of Chronicity in Low Back Pain.Diagnostics (Basel, Switzerland) · 2023Article
- A feasibility study on yoga's mechanism of action for chronic low back pain: psychological and neurophysiological changes, including global gene expression and DNA methylation, following a yoga intervention for chronic low back pain.Pilot and feasibility studies · 2022Article
- Sex-Related Pain Behavioral Differences following Unilateral NGF Injections in a Rat Model of Low Back Pain.Biology · 2022Article
- Acute inflammatory response via neutrophil activation protects against the development of chronic pain.Science translational medicine · 2022Article
- Neurophysiological and transcriptomic predictors of chronic low back pain: Study protocol for a longitudinal inception cohort study.Research in nursing & health · 2022Article
- Investigating key predictors of persistent low back pain: A focus on psychological stress.Applied nursing research : ANR · 2021Article
- The Potential Role of Preoperative Pain, Catastrophizing, and Differential Gene Expression on Pain Outcomes after Pediatric Spinal Fusion.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2021Article
- A Role for Global DNA Methylation Level andFrontiers in pain research (Lausanne, Switzerland) · 2021Article
- AAAPT Diagnostic Criteria for Acute Low Back Pain with and Without Lower Extremity Pain.Pain medicine (Malden, Mass.) · 2020Review
- Can Implementation of Genetics and Pharmacogenomics Improve Treatment of Chronic Low Back Pain?Pharmaceutics · 2020Review
- Contribution of COMT and BDNF Genotype and Expression to the Risk of Transition From Acute to Chronic Low Back Pain.The Clinical journal of pain · 2020Article
- Experimental Pain Sensitivity in Subjects with Temporomandibular Disorders and Multiple Other Chronic Pain Conditions: The OPPERA Prospective Cohort Study.Journal of oral & facial pain and headache · 2020Article
- A Multidisciplinary Focus Review of Musculoskeletal Disorders Among Operating Room Personnel.Journal of multidisciplinary healthcare · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesLow back pain (LBP) is the second most frequently diagnosed pain condition in the United States, and although a majority of individuals have resolution of pain during the acute period, an estimated 40% of individuals will experience persistent pain. Given the heterogenous nature of LBP, this study sought to describe and compare somatosensory and molecular (gene expression) profiles between individuals with acute LBP and healthy no-pain controls.
methodsUsing a previously established protocol, we comprehensively assessed somatosensory parameters among 31 no-pain control participants and 31 participants with acute LBP. Samples of whole blood were drawn to examine mRNA expression of candidate genes involved in the transduction, maintenance, and modulation of pain.
resultsThe acute LBP group exhibited increased pain sensitivity to cold stimuli, mechanical stimuli, including mechanical temporal summation at both the painful back area and remote location suggesting a mechanism of enhanced central nervous system excitability. In addition, deep tissue-specific peripheral sensitization was suggested due to significant differences in pressure pain threshold of the painful back area, but not the remote body site. Several genes that were differentially expressed were significantly associated with somatosensory alterations identified in the acute LBP group. DISCUSSION: Acute LBP participants showed selective pain sensitivity enhancement and differential gene expression profiles compared with pain-free controls. Further research to characterize pain-associated somatosensory changes in the context of altered mRNA expression levels may provide insight on the molecular underpinnings of maladaptive chronic pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.