Evidence map›Paper›PMID 26736013›Full record

ArticleACS nano2016

Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications.

Xiang Wu, Yuanwei Zhang, Kendra Takle, Osman Bilsel, Zhanjun Li, Hyungseok Lee, Zijiao Zhang, Dongsheng Li, Wei Fan, Chunying Duan and 4 more

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
34.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 443 citations in OpenAlex.

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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Xiang WuState Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian, 116012, People's Republic of China.
Yuanwei Zhang
Kendra Takle
Osman Bilsel
Zhanjun Li
Hyungseok Lee
Zijiao ZhangDepartment of Materials Science & Engineering, Zhejiang University , Hangzhou, 310027, People's Republic of China.
Dongsheng LiMaterials Sciences, Physical and Computational Sciences Directorate, Pacific Northwest National Laboratory , Richland, Washington 99352, United States.
Wei FanChemical Engineering Department, University of Massachusetts , Amherst, Massachusetts 01003, United States.
Chunying DuanState Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian, 116012, People's Republic of China.
Emory M ChanThe Molecular Foundry, Lawrence Berkeley National Laboratory , Berkeley, California 94720, United States.
Carlos Lois
Yang Xiang
Gang Han
University of Massachusetts Chan Medical School · USDalian University · CNDalian University of Technology · CNLawrence Berkeley National Laboratory · USPacific Northwest National Laboratory · USUniversity of Massachusetts Amherst · USZhejiang University · CN

Funding

Wireless Optogenetics by relay nano-illuminatorsR01MH103133 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HAN, GANG · 2013 to 2016
$1.3M
NIMH NIH HHS R01 MH103133NIMH NIH HHS R01MH103133
6 · The paper itself

Abstract

Near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. Here, we achieved significantly enhanced upconversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb(3+)) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.

Indexed as

AnimalsEnergy TransferFemaleFluorescent DyesHippocampusIndolesLuminescent MeasurementsMiceMice, Inbred BALB CNanoparticlesNeuronsOptical ImagingOptogeneticsPatch-Clamp TechniquesPolymethyl MethacrylatePrimary Cell CultureFluorescent DyesIndolesPolymethyl MethacrylateYtterbiumYttriumbioimagingcore/active shell structuredye-sensitizingnear-infraredoptogeneticsupconversion nanoparticles

Identifiers

PMID26736013
PMCPMC4913696
OpenAlexW2226188670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.