Evidence map›Paper›PMID 26735697›Full record

ReviewAnnual review of immunology2016

Transcriptional Control of Dendritic Cell Development.

Theresa L Murphy, Gary E Grajales-Reyes, Xiaodi Wu, Roxane Tussiwand, Carlos G Briseño, Arifumi Iwata, Nicole M Kretzer, Vivek Durai, Kenneth M Murphy

Abstract readReview
In one paragraph

Review in Annual review of immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 256 papers.

0numbers the graph read from it
0cells of the map it votes in
256citing papers in PubMed
27.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

256 citing papers in PubMed, 463 citations in OpenAlex.

  1. Nutrients · 2024
    Trial
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  4. Biochemistry and biophysics reports · 2026
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196 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Theresa L MurphyDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
Gary E Grajales-ReyesDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
Xiaodi WuDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
Roxane TussiwandDepartment of Biomedicine, University of Basel, 4058 Basel, Switzerland.
Carlos G BriseñoDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
Arifumi IwataDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
Nicole M KretzerDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
Vivek DuraiDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
Kenneth M MurphyDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
Washington University in St. Louis · USHoward Hughes Medical Institute · USUniversity of Basel · CH

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
The role of cross-presentation of self-antigens by dendritic cells in type 1 diabetesF30DK108498 · NIDDK · WASHINGTON UNIVERSITY · PI DURAI, VIVEK · 2015 to 2017
$109k
Deciphering CD8 Dendritic Cell Development for the Improvement of VaccineF31CA189491 · NCI · WASHINGTON UNIVERSITY · PI GRAJALES-REYES, GARY E. · 2014 to 2016
$89k
Howard Hughes Medical InstituteNCI NIH HHS F31 CA189491NCI NIH HHS P30 CA091842NIDDK NIH HHS F30 DK108498
6 · The paper itself

Abstract

The dendritic cells (DCs) of the immune system function in innate and adaptive responses by directing activity of various effector cells rather than serving as effectors themselves. DCs and closely related myeloid lineages share expression of many surface receptors, presenting a challenge in distinguishing their unique in vivo functions. Recent work has taken advantage of unique transcriptional programs to identify and manipulate murine DCs in vivo. This work has assigned several nonredundant in vivo functions to distinct DC lineages, consisting of plasmacytoid DCs and several subsets of classical DCs that promote different immune effector modules in response to pathogens. In parallel, a correspondence between human and murine DC subsets has emerged, underlying structural similarities for the DC lineages between these species. Recent work has begun to unravel the transcriptional circuitry that controls the development and diversification of DCs from common progenitors in the bone marrow.

Indexed as

Gene Expression RegulationImmunity, CellularAnimalsBone Marrow CellsCell DifferentiationCell LineageDendritic CellsGene Expression ProfilingGene Regulatory NetworksHumansMiceTranscriptional Activationcommon dendritic progenitordendritic celllineage commitmenttranscription factors

Identifiers

PMID26735697
PMCPMC5135011
OpenAlexW2108449579

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.