Evidence map›Paper›PMID 26735627›Full record

Observational studyAmerican journal of respiratory and critical care medicine2016

Incidence and Risk Factors for Intensive Care Unit-related Post-traumatic Stress Disorder in Veterans and Civilians.

Mayur B Patel, James C Jackson, Alessandro Morandi, Timothy D Girard, Christopher G Hughes, Jennifer L Thompson, Amy L Kiehl, Mark R Elstad, Mitzi L Wasserstein, Richard B Goodman and 5 more

2 registry-linked trialsOpen access · greenAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03991611 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Tailored Multicomponent Program for Discomfort Reduction in Critically il Patients May Decrease Post-traumatic Stress Disorder in General ICU Survivors at One Year

TypeinterventionalSponsorCentre Hospitalier of ChartresRan2019 to 2023Enrolled3,312ConditionsCritical IllnessArmsAdministration of the IPREA3 questionnaire, Immediate feedback through electronic reminder messages, Targeted interventions in each ICU to reduce discomforts, 6 months follow-up to assess the prevalence of PTSD symptoms, 1 year follow-up to assess psychiatric morbidity
NCT07701850 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Influence of Standard Ventilator Setting Adjustments on Dyspnea Experienced in Awake Mechanically-ventilated Patients: A Pilot Study

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2026 to 2027Enrolled20ConditionsRespiratory Failure, Dyspnea During Mechanical Ventilation, Mechanical VentilationArmsChange to VC/AC, Change in Tidal Volume, Change in inspiratory flow, Change in PEEP, Change to PSV
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 107 citations in OpenAlex.

  1. Trial
  2. Posttraumatic Growth, Anxiety, Depression, and Posttraumatic Stress Disorder in Intensive Care Unit Survivors.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Observational
  7. Article
  8. Observational
  9. Observational
  10. Review
  11. Article
  12. Observational
  13. Article
  14. Review
  15. Article
  16. Article
  17. Predicting brain function status changes in critically ill patients via Machine learning.Journal of the American Medical Informatics Association : JAMIA · 2021
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Mayur B Patel1 Surgical Services, Nashville VA Medical Center, Tennessee Valley Healthcare System, U.S. Department of Veterans Affairs, Nashville, Tennessee.ORCID http://orcid.org/0000-0001-5230-0871
James C Jackson3 Geriatric Research, Education, and Clinical Center, Nashville VA Medical Center, Tennessee Valley Healthcare System, U.S. Department of Veterans Affairs, Nashville, Tennessee.
Alessandro Morandi6 Department of Rehabilitation and Aged Care Unit, Hospital Ancelle, Cremona, Italy.
Timothy D Girard3 Geriatric Research, Education, and Clinical Center, Nashville VA Medical Center, Tennessee Valley Healthcare System, U.S. Department of Veterans Affairs, Nashville, Tennessee.
Christopher G Hughes8 Anesthesia Service, Nashville VA Medical Center, Tennessee Valley Healthcare System, U.S. Department of Veterans Affairs, Nashville, Tennessee.
Jennifer L Thompson10 Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee.
Amy L Kiehl4 Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt Center for Health Services Research, Vanderbilt University Medical Center, Nashville, Tennessee.
Mark R Elstad11 George E. Wahlen Department of Veterans Affairs Medical Center, VA Salt Lake City Health Care System, U.S. Department of Veterans Affairs, Salt Lake City, Utah.
Mitzi L Wasserstein11 George E. Wahlen Department of Veterans Affairs Medical Center, VA Salt Lake City Health Care System, U.S. Department of Veterans Affairs, Salt Lake City, Utah.
Richard B Goodman13 Seattle Division, VA Puget Sound Health Care System, U.S. Department of Veterans Affairs, Seattle, Washington.
Jean C Beckham15 Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham Veterans Affairs Medical Center, U.S. Department of Veterans Affairs Medical Center, Durham, North Carolina.
Rameela Chandrasekhar10 Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee.
Robert S Dittus3 Geriatric Research, Education, and Clinical Center, Nashville VA Medical Center, Tennessee Valley Healthcare System, U.S. Department of Veterans Affairs, Nashville, Tennessee.
E Wesley Ely3 Geriatric Research, Education, and Clinical Center, Nashville VA Medical Center, Tennessee Valley Healthcare System, U.S. Department of Veterans Affairs, Nashville, Tennessee.
Pratik P Pandharipande8 Anesthesia Service, Nashville VA Medical Center, Tennessee Valley Healthcare System, U.S. Department of Veterans Affairs, Nashville, Tennessee.
United States Department of Veterans Affairs · USVanderbilt University · USGruppo di Ricerca Geriatrica · ITUniversity of Washington · USVanderbilt University Medical Center · USVA Tennessee Valley Healthcare System · USVeterans Health Administration · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
The MIND USA StudyR01AG035117 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ELY, E WESLEY · 2011 to 2016
$7.3M
Altering Sedation Paradigms to Improve Brain Injury and Survival in Severe SepsisR01HL111111 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PANDHARIPANDE, PRATIK · 2012 to 2017
$3.7M
The MIND ICU StudyR01AG027472 · NIA · VANDERBILT UNIVERSITY · PI ELY, E WESLEY · 2006 to 2010
$3.0M
Predictors of Cognitive Impairment in Survivors of Critical IllnessK23AG034257 · NIA · VANDERBILT UNIVERSITY · PI GIRARD, TIMOTHY D · 2009 to 2013
$684k
Executive Dysfunction and Functional Impairment in Elderly ICU SurvivorsK23AG031322 · NIA · VANDERBILT UNIVERSITY · PI JACKSON, JAMES C. · 2008 to 2012
$556k
NCATS NIH HHS UL1 TR000445NHLBI NIH HHS R01 HL111111NIA NIH HHS K23 AG031322NIA NIH HHS K23 AG034257NIA NIH HHS R01 AG027472NIA NIH HHS R01 AG035117
6 · The paper itself

Abstract

rationaleThe incidence and risk factors of post-traumatic stress disorder (PTSD) related to the intensive care unit (ICU) experience have not been reported in a mixed veteran and civilian cohort.

objectivesTo describe the incidence and risk factors for ICU-related PTSD in veterans and civilians.

methodsThis is a prospective, observational, multicenter cohort enrolling adult survivors of critical illness after respiratory failure and/or shock from three Veterans Affairs and one civilian hospital. After classifying those with/without preexisting PTSD (i.e., PTSD before hospitalization), we then assessed all subjects for ICU-related PTSD at 3 and 12 months post hospitalization. MEASUREMENTS AND MAIN

resultsOf 255 survivors, 181 and 160 subjects were assessed for ICU-related PTSD at 3- and 12-month follow-up, respectively. A high probability of ICU-related PTSD was found in up to 10% of patients at either follow-up time point, whether assessed by PTSD Checklist Event-Specific Version (score ≥ 50) or item mapping using the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV). In the multivariable regression, preexisting PTSD was independently associated with ICU-related PTSD at both 3 and 12 months (P < 0.001), as was preexisting depression (P < 0.03), but veteran status was not a consistent independent risk factor for ICU-related PTSD (3-month P = 0.01, 12-month P = 0.48).

conclusionsThis study found around 1 in 10 ICU survivors experienced ICU-related PTSD (i.e., PTSD anchored to their critical illness) in the year after hospitalization. Preexisting PTSD and depression were strongly associated with ICU-related PTSD.

Indexed as

AgedCohort StudiesCritical CareCritical IllnessFemaleFollow-Up StudiesHospitalizationHumansIncidenceIntensive Care UnitsMaleMiddle AgedProspective StudiesRisk FactorsStress Disorders, Post-TraumaticSurvivorsintensive care unitpost-traumatic stress disorderveterans

Identifiers

PMID26735627
PMCPMC4910886
OpenAlexW2425223159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.