Evidence map›Paper›PMID 26735581›Full record

ArticleOncotarget2016

Chicoric acid binds to two sites and decreases the activity of the YopH bacterial virulence factor.

Alicja Kuban-Jankowska, Kamlesh K Sahu, Magdalena Gorska, Jack A Tuszynski, Michal Wozniak

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Alicja Kuban-JankowskaDepartment of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland.
Kamlesh K SahuDepartment of Physics, University of Alberta, Edmonton, Canada.
Magdalena GorskaDepartment of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland.
Jack A TuszynskiDepartment of Physics, University of Alberta, Edmonton, Canada.
Michal WozniakDepartment of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland.
Gdańsk Medical University · PLUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chicoric acid (CA) is a phenolic compound present in dietary supplements with a large spectrum of biological properties reported ranging from antioxidant, to antiviral, to immunostimulatory properties. Due to the fact that chicoric acid promotes phagocytic activity and was reported as an allosteric inhibitor of the PTP1B phosphatase, we examined the effect of CA on YopH phosphatase from pathogenic bacteria, which block phagocytic processes of a host cell. We performed computational studies of chicoric acid binding to YopH as well as validation experiments with recombinant enzymes. In addition, we performed similar studies for caffeic and chlorogenic acids to compare the results. Docking experiments demonstrated that, from the tested compounds, only CA binds to both catalytic and secondary binding sites of YopH. Our experimental results showed that CA reduces activity of recombinant YopH phosphatase from Yersinia enterocolitica and human CD45 phosphatase. The inhibition caused by CA was irreversible and did not induce oxidation of catalytic cysteine. We proposed that inactivation of YopH induced by CA is involved with allosteric inhibition by interacting with essential regions responsible for ligand binding.

Indexed as

Bacterial Outer Membrane ProteinsBinding SitesCaffeic AcidsCatalytic DomainChlorogenic AcidCysteineMolecular Docking SimulationMolecular Dynamics SimulationProtein Tyrosine Phosphatase, Non-Receptor Type 1Protein Tyrosine PhosphatasesSuccinatesVirulence FactorsYersinia enterocoliticaBacterial Outer Membrane Proteinscaffeic acidCaffeic Acidschicoric acidChlorogenic AcidCysteineProtein Tyrosine Phosphatase, Non-Receptor Type 1Protein Tyrosine PhosphatasesPTPN1 protein, humanSuccinatesVirulence FactorsyopH protein, Yersiniacaffeic acidchicoric acidchlorogenic acidImmune responseImmunityImmunology and Microbiology Sectionprotein tyrosine phosphatase YopH

Identifiers

PMID26735581
PMCPMC4823031
OpenAlexW2289558061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.