ArticleAutophagy2015
Evidence for autophagy-dependent pathways of rRNA turnover in Arabidopsis.
Article in Autophagy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 94 citations in OpenAlex.
- Article
- An active RNA transport mechanism into plant vacuoles.Nucleic acids research · 2026Article
- NBR1-Mediated Selective Autophagy in Plant Development and Stress Responses.Plants (Basel, Switzerland) · 2026Review
- Single-cell proteomics of Arabidopsis leaf mesophyll reveals dynamic protein responses to water-deficit stress.Genome biology · 2026Article
- Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation.bioRxiv : the preprint server for biology · 2025Article
- Vacuolar phosphatases are essential for efficient nucleotide salvage in Arabidopsis.Journal of experimental botany · 2025Article
- Analysis of Autophagy Under Abiotic Stress in Arabidopsis Seedlings Expressing the GFP-ATG8 Autophagosome Marker.Current protocols · 2025Article
- Mobilization and recycling of intracellular phosphorus in response to availability.Quantitative plant biology · 2025Review
- A tissue-specific rescue strategy reveals the local roles of autophagy in leaves and seeds for resource allocation.Plant physiology · 2024Article
- Autophagy: a key player in the recovery of plants from heat stress.Journal of experimental botany · 2024Review
- RNS2 is required for the biogenesis of a wounding responsive 16 nts tsRNA in Arabidopsis thaliana.Plant molecular biology · 2024Article
- Metabolic footprints in phosphate-starved plants.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Review
- Extracellular RNA: mechanisms of secretion and potential functions.Journal of experimental botany · 2023Article
- Variability and limits of nitrogen and phosphorus resorption during foliar senescence.Plant communications · 2023Review
- Biological insights from multi-omics analysis strategies: Complex pleotropic effects associated with autophagy.Frontiers in plant science · 2023Article
- Adaptive strategies of plants to conserve internal phosphorus under P deficient condition to improve P utilization efficiency.Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Review
- Defects in autophagy lead to selective in vivo changes in turnover of cytosolic and organelle proteins in Arabidopsis.The Plant cell · 2022Article
- RNA biology takes root in plant systems.Plant direct · 2022Article
- γ-Aminobutyric acid plays a key role in plant acclimation to a combination of high light and heat stress.Plant physiology · 2022Article
- Complex Changes in Membrane Lipids Associated with the Modification of Autophagy inMetabolites · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ribosomes account for a majority of the cell's RNA and much of its protein and represent a significant investment of cellular resources. The turnover and degradation of ribosomes has been proposed to play a role in homeostasis and during stress conditions. Mechanisms for the turnover of rRNA and ribosomal proteins have not been fully elucidated. We show here that the RNS2 ribonuclease and autophagy participate in RNA turnover in Arabidopsis thaliana under normal growth conditions. An increase in autophagosome formation was seen in an rns2-2 mutant, and this increase was dependent on the core autophagy genes ATG9 and ATG5. Autophagosomes and autophagic bodies in rns2-2 mutants contain RNA and ribosomes, suggesting that autophagy is activated as an attempt to compensate for loss of rRNA degradation. Total RNA accumulates in rns2-2, atg9-4, atg5-1, rns2-2 atg9-4, and rns2-2 atg5-1 mutants, suggesting a parallel role for autophagy and RNS2 in RNA turnover. rRNA accumulates in the vacuole in rns2-2 mutants. Vacuolar accumulation of rRNA was blocked by disrupting autophagy via an rns2-2 atg5-1 double mutant but not by an rns2-2 atg9-4 double mutant, indicating that ATG5 and ATG9 function differently in this process. Our results suggest that autophagy and RNS2 are both involved in homeostatic degradation of rRNA in the vacuole.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.