ArticleJournal of affective disorders2016
Lipid peroxidation biomarkers in adolescents with or at high-risk for bipolar disorder.
Article in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder.Bipolar disorders · 2016Pooled it
- Biomarkers of bipolar disorder in omics and neuroimaging.Journal of pharmaceutical analysis · 2025Review
- Lipid oxidation in young patients with newly diagnosed bipolar disorder and their relatives.International journal of bipolar disorders · 2025Article
- Neurexin-3 is Elevated and Associated with Cognition Status and 4-Hydroxynonenal in Bipolar Disorder.Annals of neurosciences · 2025Article
- Putative Risk Biomarkers of Bipolar Disorder in At-risk Youth.Neuroscience bulletin · 2024Review
- Superoxide dismutase and neurological disorders.IBRO neuroscience reports · 2024Review
- Oxidation of DNA and RNA in young patients with newly diagnosed bipolar disorder and relatives.Translational psychiatry · 2024Article
- Pro/antioxidant status and selenium, zinc and arsenic concentration in patients with bipolar disorder treated with lithium and valproic acid.Frontiers in molecular neuroscience · 2024Article
- Anti-Inflammatory, Antioxidant, and Neuroprotective Effects of Polyphenols-Polyphenols as an Element of Diet Therapy in Depressive Disorders.International journal of molecular sciences · 2023Review
- The Relationship between Oxidative Stress and Subjective Sleep Quality in People with Coronary Artery Disease.Brain sciences · 2022Article
- Interleukin-8 and tumor necrosis factor-alpha in youth with mood disorders-A longitudinal study.Frontiers in psychiatry · 2022Article
- Metabolomic Identification of Serum Exosome-Derived Biomarkers for Bipolar Disorder.Oxidative medicine and cellular longevity · 2022Article
- The Impact of Electroacupuncture Early Intervention on the Brain Lipidome in a Mouse Model of Post-traumatic Stress Disorder.Frontiers in molecular neuroscience · 2022Article
- Oxidative Stress Markers and Antioxidant Enzymes in Children and Adolescents with Depressive Disorder and Impact of Omega-3 Fatty Acids in Randomised Clinical Trial.Antioxidants (Basel, Switzerland) · 2021Article
- Concepts of Neuroinflammation and Their Relationship With Impaired Mitochondrial Functions in Bipolar Disorder.Frontiers in behavioral neuroscience · 2021Review
- Association Between Sphingolipids and Cardiopulmonary Fitness in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- The Effect of Oral L-cysteine on Breast Milk and Plasma Cysteine Concentrations.Neuropsychiatric disease and treatment · 2020Article
- The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research.Bipolar disorders · 2017Review
- Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application.Progress in lipid research · 2017Review
- Serum phosphatidylinositol as a biomarker for bipolar disorder liability.Bipolar disorders · 2017Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundPrior work suggests that adult bipolar disorder (BD) is associated with increased oxidative stress and inflammation. This exploratory study examined markers of lipid and protein oxidation and inflammation in adolescents with and at varying risk for BD type I (BD-I).
methodsBlood was obtained from four groups of adolescents (9-20 years of age): (1) healthy comparison subjects with no personal or family history of psychiatric disorders (n=13), (2) subjects with no psychiatric diagnosis and at least one parent with BD-I ('high-risk', n=15), (3) subjects with at least one parent with BD-I and a diagnosis of depressive disorder not-otherwise-specified ('ultra-high-risk', n=20), and (4) first-episode patients exhibiting mixed or manic symptoms that received a diagnosis of BD-I (n=16). Plasma levels of lipid peroxidation (LPH, 4-HNE, 8-ISO), protein carbonyl, and inflammation (IL-1α-β, IL-6, IL-10, IFNγ, TNFα) were assessed using analysis of variance and covariance models.
resultsLPH was lower in adolescents with fully syndromal BD than controls, while LPH levels in the at-risk groups were between healthy controls and fully syndromal BD. Post-hoc analysis showed a non-significant increase in the (4-HNE+8-ISO)/LPH ratio suggesting a potential conversion of LPH into late-stage markers of lipid peroxidation. There were no significant differences among protein carbonyl content and inflammatory markers.
conclusionsIn adolescents, fully syndromal BD is associated with significant reductions in LPH levels, and LPH levels decrease along the spectrum of risk for BD-I. Quantifying lipid peroxidation in longitudinal studies may help clarify the role of LPH in BD risk progression.
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