ArticlePloS one2016
Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Total Synthesis of Antimalarial Macrolide Strasseriolide A by Ni/Zr-Mediated Reductive Ketone Coupling.The Journal of organic chemistry · 2026Article
- Novel Antiplasmodial Natural Products Identified Through a Modified Bioluminescence-Based Rate-of-Kill Assay.Biomedicines · 2026Article
- Antimalarial activity of root extract of Tephrosia villosa L. Pers. (Fabaceae) on Plasmodium berghei-infected mice.Scientific reports · 2025Article
- Total Synthesis of Tosyl-Samroiyotmycin A and Its Biological Profiling.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Screening inhibitors against the Ef-Tu of Fusobacterium nucleatum: a docking, ADMET and PBPK assessment study.Molecular diversity · 2024Article
- Yamaguchi esterification: a key step toward the synthesis of natural products and their analogs-a review.Frontiers in chemistry · 2024Review
- Strasseriolides display in vitro and in vivo activity against trypanosomal parasites and cause morphological and size defects in Trypanosoma cruzi.PLoS neglected tropical diseases · 2023Article
- Antiparasitic Meroterpenoids Isolated fromPharmaceutics · 2023Article
- Antiparasitic Ovalicin Derivatives fromMolecules (Basel, Switzerland) · 2022Article
- Antiplasmodial Activity of 80% Methanolic Extract and Solvent Fractions of Stem Bark ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- New Compounds with Bioisosteric Replacement of Classic Choline Kinase Inhibitors Show Potent Antiplasmodial Activity.Pharmaceutics · 2021Article
- Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat EndophyticPharmaceuticals (Basel, Switzerland) · 2021Article
- Evaluation of Antiplasmodial Activity of Hydroalcoholic Crude Extract and Solvent Fractions ofInfection and drug resistance · 2021Article
- A Photoalkylative Fluorogenic Probe of Guttiferone A for Live Cell Imaging and Proteome Labeling inMolecules (Basel, Switzerland) · 2020Article
- Creating and screening natural product libraries.Natural product reports · 2020Review
- Signalling and Bioactive Metabolites fromMolecules (Basel, Switzerland) · 2020Article
- Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae).BMC complementary medicine and therapies · 2020Article
- Evaluation of Antimalarial Activity of Hydromethanolic Crude Extract and Solvent Fractions of the Leaves ofJournal of experimental pharmacology · 2019Article
- Review
- The Stl repressor fromFEBS open bio · 2018Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to the low structural diversity within the set of antimalarial drugs currently available in the clinic and the increasing number of cases of resistance, there is an urgent need to find new compounds with novel modes of action to treat the disease. Microbial natural products are characterized by their large diversity provided in terms of the chemical complexity of the compounds and the novelty of structures. Microbial natural products extracts have been underexplored in the search for new antiparasitic drugs and even more so in the discovery of new antimalarials. Our objective was to find new druggable natural products with antimalarial properties from the MEDINA natural products collection, one of the largest natural product libraries harboring more than 130,000 microbial extracts. In this work, we describe the optimization process and the results of a phenotypic high throughput screen (HTS) based on measurements of Plasmodium lactate dehydrogenase. A subset of more than 20,000 extracts from the MEDINA microbial products collection has been explored, leading to the discovery of 3 new compounds with antimalarial activity. In addition, we report on the novel antiplasmodial activity of 4 previously described natural products.
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